A separate assay of released and liposomal encapsulated eribulin in dog plasma by liquid chromatography with tandem mass spectrometry for its application to a pharmacokinetic study.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202200048
Abstract: Eribulin has been used as a drug for the treatment of metastatic breast cancer and liposomal formulation of eribulin (E7389-LF) is under development to achieve a wider therapeutic index. It is important to separately determine… read more here.
Keywords: dog plasma; plasma liquid; plasma; separate assay ... See more keywords
Eribulin improves tumor oxygenation demonstrated by 18F-DiFA hypoxia imaging, leading to radio-sensitization in human cancer xenograft models
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-021-05544-4
Abstract: Eribulin, an inhibitor of microtubule dynamics, is known to show antitumor effects through its remodeling activity in the tumor vasculature. However, the extent to which the improvement of tumor hypoxia by eribulin affects radio-sensitivity remains… read more here.
Keywords: tumor oxygenation; 18f difa; hypoxia; eribulin ... See more keywords
Phase II trial of eribulin in patients who do not achieve pathologic complete response (pCR) following neoadjuvant chemotherapy
Sign Up to like & getrecommendations! Published in 2020 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-020-05563-z
Abstract: Purpose Women with residual invasive breast cancer at the primary site or axillary lymph nodes following neoadjuvant chemotherapy have a high risk of recurrence. Eribulin improves survival in patients with metastatic breast cancer who progress… read more here.
Keywords: eribulin; neoadjuvant chemotherapy; following neoadjuvant; breast cancer ... See more keywords
Avelumab in Combination with Eribulin Mesylate in Metastatic Urothelial Carcinoma: BTCRC GU-051, a Phase 1b Study.
Sign Up to like & getrecommendations! Published in 2021 at "European urology focus"
DOI: 10.1016/j.euf.2021.03.005
Abstract: BACKGROUND Patients with metastatic urothelial carcinoma (mUC) have poor prognosis, so further development of novel combinations for these patients is needed. OBJECTIVE To assess the safety and efficacy of eribulin mesylate (eribulin) with avelumab in… read more here.
Keywords: combination; study; urothelial carcinoma; metastatic urothelial ... See more keywords
Systematic review of Real-World effectiveness of eribulin for locally advanced or metastatic breast cancer
Sign Up to like & getrecommendations! Published in 2020 at "Current Medical Research and Opinion"
DOI: 10.1080/03007995.2020.1835853
Abstract: Abstract Background Eribulin mesylate (eribulin) is indicated for patients with metastatic breast cancer (MBC) who have previously received at least two chemotherapies in the US and for patients with locally advanced breast cancer (LABC) or… read more here.
Keywords: breast; breast cancer; metastatic breast; eribulin ... See more keywords
Pharmacodynamic Model-Based Safety Management of Eribulin-Induced Myelosuppression in Patients With Breast Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Therapeutic Drug Monitoring"
DOI: 10.1097/ftd.0000000000001036
Abstract: Supplemental Digital Content is Available in the Text. Background: Neutropenia is a major dose-limiting toxicity of cancer chemotherapy. Semimechanistic mathematical models have been applied to describe the time course of neutrophil counts. The objectives of… read more here.
Keywords: safety management; neutrophil counts; model; eribulin ... See more keywords
Liposome-Encapsulated Eribulin Shows Enhanced Antitumor Activity over Eribulin for Combination Therapy with Anti–PD-1 Antibody
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-22-0475
Abstract: Abstract Eribulin is a microtubule dynamics inhibitor with tumor microenvironment modulation activity such as vascular remodeling activity. Here, we investigated antitumor and immunomodulatory activities of eribulin and its liposomal formulation (eribulin-LF) as monotherapies or in… read more here.
Keywords: antitumor activity; eribulin eribulin; combination; activity eribulin ... See more keywords
Abstract 3117: Eribulin is a novel TERT-targeting inhibitor that penetrates into intracerebrally grown glioblastomas and suppresses their growth in mice
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-3117
Abstract: [Introduction] No effective molecular targeting therapy has been clinically developed for patients with glioblastoma (GBM) despite of intense genome analysis. Approximately 60-80% of GBM harbor mutations in the promoter region of TERT that leads to… read more here.
Keywords: novel tert; cell; mice; tert ... See more keywords
Abstract 6397: Eribulin acts as an immune adjuvant to enhance the antitumor efficacy of STING agonists in triple-negative breast cancer models
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6397
Abstract: Triple-negative breast cancer (TNBC) is a heterogenous subtype of breast cancer lacking effective targeted treatment options. However, TNBC typically has a higher mutational burden and greater degree of immunogenicity than other breast tumors, making immunotherapy… read more here.
Keywords: sting agonists; breast; breast cancer; eribulin ... See more keywords
Abstract P4-02-01: Eribulin induces vascular remodeling and reoxygenation in advanced breast cancer patients: A comparative study with bevacizumab
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs16-p4-02-01
Abstract: Purpose: Eribulin mesylate (eribulin) is a first-in-class halichondrin B-based microtubule dynamics inhibitor. To understand the mechanism of vascular remodeling of eribulin, we compared optical hemodynamic and blood biomarker changes between eribulin and bevacizumab. Methods: Patients… read more here.
Keywords: bevacizumab; study; breast cancer; vascular remodeling ... See more keywords
Eribulin improved the overall survival from the initiation of first-line chemotherapy for HER2-negative advanced breast cancer: a multicenter retrospective study
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DOI: 10.1186/s12885-021-09137-0
Abstract: Background Eribulin methylate (eribulin) improved the overall survival (OS) of eribulin-treated patients with HER2-negative advanced breast cancer (ABC) in prospective and retrospective studies. However, the effect of eribulin on OS as first-line chemotherapy and the… read more here.
Keywords: eribulin; her2 negative; line; first line ... See more keywords