Avelumab in Combination with Eribulin Mesylate in Metastatic Urothelial Carcinoma: BTCRC GU-051, a Phase 1b Study.
Sign Up to like & getrecommendations! Published in 2021 at "European urology focus"
DOI: 10.1016/j.euf.2021.03.005
Abstract: BACKGROUND Patients with metastatic urothelial carcinoma (mUC) have poor prognosis, so further development of novel combinations for these patients is needed. OBJECTIVE To assess the safety and efficacy of eribulin mesylate (eribulin) with avelumab in… read more here.
Keywords: combination; study; urothelial carcinoma; metastatic urothelial ... See more keywords
Synthesis of the C1–C13 fragment of eribulin mesylate
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DOI: 10.1016/j.tet.2019.06.050
Abstract: Abstract Synthesis of the C1–C13 fragment of eribulin mesylate has been accomplished. It features a highly stereoselective construction of a trans-dihydropyran framework using three key reactions: (1) Sharpless epoxidation, (2) regioselective ring opening, and (3)… read more here.
Keywords: synthesis c13; fragment eribulin; c13 fragment; eribulin mesylate ... See more keywords
Stereoselective Synthesis of Northern Fragment of Eribulin Mesylate from d-Mannose
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DOI: 10.1055/s-0036-1591769
Abstract: Stereoselective synthesis of northern fragment of eribulin mesylate is reported by coupling of the C1–C13 fragment with the C28–C35 fragment. The key steps involved in this synthesis are butyllithium-facilitated coupling between sulfone and aldehyde, then… read more here.
Keywords: northern fragment; stereoselective synthesis; fragment eribulin; synthesis northern ... See more keywords