Reconstructing ERK Signaling in the Drosophila Embryo from Fixed Images.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6424-6_25
Abstract: The early Drosophila embryo provides unique opportunities for quantitative studies of ERK signaling. This system is characterized by simple anatomy, the ease of obtaining large numbers of staged embryos, and the availability of powerful tools… read more here.
Keywords: drosophila embryo; erk activation; reconstructing erk; embryo ... See more keywords
ERK Activation Pathways Downstream of GPCRs.
Sign Up to like & getrecommendations! Published in 2018 at "International review of cell and molecular biology"
DOI: 10.1016/bs.ircmb.2018.02.003
Abstract: GPCRs, the 7-TM receptors, represent a class of cell surface receptors which modulate a variety of physiological responses. The serpentine structure in addition to contributing the diversity of stimuli these receptors can sense also provides… read more here.
Keywords: erk activation; activation pathways; downstream gpcrs; activation ... See more keywords
Imatinib mesylate elicits extracellular signal-related kinase (ERK) activation and enhances the survival of γ-irradiated epithelial cells.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.10.095
Abstract: Imatinib mesylate, commercially known as Gleevec/Glivec, is the first targeted anticancer drug that inhibits activity of the tyrosine kinases, c-ABL, c-KIT, and PDGFR. A number of studies have shown that treatment with imatinib mesylate elicits… read more here.
Keywords: erk activation; imatinib mesylate; mesylate; mesylate elicits ... See more keywords
Initial analysis of peripheral lymphocytic extracellular signal related kinase activation in autism.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of psychiatric research"
DOI: 10.1016/j.jpsychires.2016.09.003
Abstract: BACKGROUND Dysregulation of extracellular signal-related kinase (ERK) activity has been potentially implicated in the pathophysiology of autistic disorder (autism). ERK is part of a central intracellular signaling cascade responsible for a myriad of cellular functions.… read more here.
Keywords: erk activation; autism; analysis; erk ... See more keywords
ERK activation precedes Purkinje cell loss in mice with Spinocerebellar ataxia type 17
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.135337
Abstract: Spinocerebellar ataxia type17 (SCA17) is an autosomal dominant neurodegenerative disease caused by CAG expansion in the gene encoding the TATA-binding protein (TBP). The neurological features of SCA17 are Purkinje cell loss and gliosis. We have… read more here.
Keywords: erk activation; erk; purkinje cell; mice ... See more keywords
Classical RAS proteins are not essential for paradoxical ERK activation induced by RAF inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2113491119
Abstract: Significance RAF inhibitors unexpectedly induce ERK activation in normal and oncogenic RAS tumor cells, making them unsuitable for treating RAS-driven cancers. The precise mechanism of this paradox is not fully understood but is believed to… read more here.
Keywords: paradoxical erk; erk activation; raf; raf inhibitors ... See more keywords
ERK activation and autophagy impairment are central mediators of irinotecan-induced steatohepatitis
Sign Up to like & getrecommendations! Published in 2018 at "Gut"
DOI: 10.1136/gutjnl-2016-312485
Abstract: Objective Preoperative chemotherapy with irinotecan is associated with the development of steatohepatitis, which increases the risk of perioperative morbidity and mortality for liver surgery. The molecular mechanisms of this chemotherapeutic complication are widely unknown. Design… read more here.
Keywords: autophagy impairment; irinotecan induced; erk activation; steatohepatitis ... See more keywords
Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells: Implications for Targeted Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-21-0964
Abstract: Abstract Pancreatic ductal adenocarcinoma (PDAC) remains an aggressive disease that is expected to become the second cause of cancer fatalities during the next decade. As therapeutic options are limited, novel targets, and agents for therapeutic… read more here.
Keywords: cancer; erk activation; src family; pdac ... See more keywords
Cobimetinib Sensitizes Cervical Cancer to Paclitaxel via Suppressing Paclitaxel-Induced ERK Activation
Sign Up to like & getrecommendations! Published in 2022 at "Pharmacology"
DOI: 10.1159/000524305
Abstract: Introduction: Chemoresistance remains the main cause of treatment failure in cervical cancer and novel therapeutic strategies are required. Cobimetinib, a potent yet selective inhibitor of MEK1 and 2, is currently used to treat melanoma clinically.… read more here.
Keywords: cervical cancer; cobimetinib; erk activation; combination ... See more keywords
Impaired PPARɣ activation by cadmium exacerbates infection-induced lung injury.
Sign Up to like & getrecommendations! Published in 2023 at "JCI insight"
DOI: 10.1172/jci.insight.166608
Abstract: Emerging data indicate an association between environmental heavy metal exposure and lung disease, including lower respiratory tract infections (LRTIs). Here, we show by single-cell RNA sequencing an increase in Pparg gene expression in lung macrophages… read more here.
Keywords: cadmium; infection; erk activation; lung injury ... See more keywords
Targeting compensatory MEK/ERK activation increases JAK inhibitor efficacy in myeloproliferative neoplasms
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Investigation"
DOI: 10.1172/jci98785
Abstract: Constitutive JAK2 signaling is central to myeloproliferative neoplasm (MPN) pathogenesis and results in activation of STAT, PI3K/AKT, and MEK/ERK signaling. However, the therapeutic efficacy of current JAK2 inhibitors is limited. We investigated the role of… read more here.
Keywords: activation; efficacy; inhibition; mek erk ... See more keywords