Live Visualization of ERK Activity in the Mouse Blastocyst Reveals Lineage-Specific Signaling Dynamics.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental cell"
DOI: 10.1016/j.devcel.2020.09.030
Abstract: FGF/ERK signaling is crucial for the patterning and proliferation of cell lineages that comprise the mouse blastocyst. However, ERK signaling dynamics have never been directly visualized in live embryos. To address whether differential signaling is… read more here.
Keywords: mouse blastocyst; erk activity; signaling dynamics; cell ... See more keywords
MAPK/ERK activity is required for the successful progression of mitosis in sea urchin embryos.
Sign Up to like & getrecommendations! Published in 2017 at "Developmental biology"
DOI: 10.1016/j.ydbio.2016.11.018
Abstract: Using sea urchin embryos, we demonstrate that the MEK/MAPK/ERK cascade is essential for the proper progression of the cell cycle. Activation of a limited fraction of MAPK/ERK is required between S-phase and M-phase. Neither DNA… read more here.
Keywords: mapk erk; mapk; sea urchin; erk activity ... See more keywords
Regulation of ERK basal and pulsatile activity control proliferation and exit from the stem cell compartment in mammalian epidermis
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2006965117
Abstract: Significance Understanding how intracellular signaling cascades control cell fate is a key issue in stem cell biology. Here we show that exit from the stem cell compartment in mammalian epidermis is characterized by pulsatile ERK… read more here.
Keywords: basal; erk; erk activity; epidermis ... See more keywords
Abstract 2833: Single-cell imaging reveals MAPK pathway reactivation in drug-tolerant melanoma cells
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-2833
Abstract: Spontaneous genetic mutations allow an initially drug-sensitive population of cancer cells to acquire a drug-resistant phenotype. However, little is known about how drug-sensitive cells first evade drug action and survive in the presence of drug,… read more here.
Keywords: single cell; mapk pathway; drug; melanoma cells ... See more keywords
A kinase translocation reporter reveals real-time dynamics of ERK activity in Drosophila
Sign Up to like & getrecommendations! Published in 2022 at "Biology Open"
DOI: 10.1242/bio.059364
Abstract: Extracellular Signal-Regulated Kinase (ERK) lies downstream of a core signalling cascade that controls all aspects of development and adult homeostasis. Recent developments have led to new tools to image and manipulate the pathway. However, visualising… read more here.
Keywords: time; reporter; drosophila; activity ... See more keywords
The role of mitosis in generating fitness heterogeneity.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cell science"
DOI: 10.1242/jcs.260103
Abstract: Cancer cells have heterogeneous fitness, and this heterogeneity stems from genetic and epigenetic sources. Here, we sought to assess the contribution of asymmetric mitosis (AM) and time on the variability of fitness in sister cells.… read more here.
Keywords: fitness heterogeneity; mitosis; erk activity;