Reduced FRG1 expression promotes angiogenesis via activation of the FGF2‐mediated ERK/AKT pathway
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13582
Abstract: Identifying novel targets that control both tumorigenesis and angiogenesis can aid in developing a more potent anti‐angiogenic therapeutic strategy. We previously reported that reduction of FRG1 is associated with increased p38‐MAPK signaling in prostate cancer… read more here.
Keywords: frg1 expression; erk akt; fgf2; reduced frg1 ... See more keywords
α-Lipoic acid attenuates oxidative stress and neurotoxicity via the ERK/Akt-dependent pathway in the mutant hSOD1 related Drosophila model and the NSC34 cell line of amyotrophic lateral sclerosis
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2018.05.019
Abstract: Amyotrophic lateral sclerosis (ALS) is a degenerative disease with a progressive loss of motor neurons in the central nervous system (CNS). However, there are unsolved problems with the therapies for this disease. α-Lipoic acid (LA)… read more here.
Keywords: antioxidant; erk akt; pathway; hsod1 ... See more keywords
Nitric oxide: Is it the culprit for the continued expansion of keloids?
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.04.040
Abstract: Keloids are characterized by excessive proliferation of fibroblasts and invasion of surrounding healthy skin. High levels of Nitric Oxide (NO) are thought to be the crucial factor within the micro-environment in promoting keloid formation. However,… read more here.
Keywords: cell; kdfs proliferation; erk akt; proliferation ... See more keywords
Dammarane-Type Saponins from Gynostemma pentaphyllum prevent hypoxia-induced neural injury through activation of ERK, Akt and CREB pathways.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b06659
Abstract: Gynostemma pentaphyllum possesses the neuroprotective bioactivity. However, the effect of gypenosides on the hypoxia-induced neural damage remains obscure. In this study, Gyp, the active fraction extracted from G. pentaphyllum, and its bioactive compounds as well… read more here.
Keywords: akt creb; erk akt; gynostemma pentaphyllum; injury ... See more keywords
From the Cover: Ion-Shedding Zinc Oxide Nanoparticles Induce Microglial BV2 Cell Proliferation via the ERK and Akt Signaling Pathways
Sign Up to like & getrecommendations! Published in 2017 at "Toxicological Sciences"
DOI: 10.1093/toxsci/kfw241
Abstract: Given the wide application of zinc oxide nanoparticles (ZnO NPs), the health hazards of these particles have attracted extensive worldwide attention. Many more studies on the biological interactions of ZnO NPs have been performed in… read more here.
Keywords: zno nps; cell proliferation; zinc; erk akt ... See more keywords
FGFR3 promotes the growth and malignancy of melanoma by influencing EMT and the phosphorylation of ERK, AKT, and EGFR
Sign Up to like & getrecommendations! Published in 2019 at "BMC Cancer"
DOI: 10.1186/s12885-019-6161-8
Abstract: BackgroundOverexpression of fibroblast growth factor receptor 3 (FGFR3) has been linked to tumor progression in many types of cancer. The role of FGFR3 in melanoma remains unclear. In this study, we aimed to uncover the… read more here.
Keywords: melanoma; erk akt; metastasis; fgfr3 ... See more keywords
Single-cell imaging of ERK and Akt activation dynamics and heterogeneity induced by G-protein-coupled receptors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cell Science"
DOI: 10.1242/jcs.259685
Abstract: ABSTRACT Kinases play key roles in signaling networks that are activated by G-protein-coupled receptors (GPCRs). Kinase activities are generally inferred from cell lysates, hiding cell-to-cell variability. To study the dynamics and heterogeneity of ERK and… read more here.
Keywords: cell; heterogeneity; erk akt; coupled receptors ... See more keywords
SULF2 promotes tumorigenesis and inhibits apoptosis of cervical cancer cells through the ERK/AKT signaling pathway
Sign Up to like & getrecommendations! Published in 2020 at "Brazilian Journal of Medical and Biological Research"
DOI: 10.1590/1414-431x20198901
Abstract: The objective of this study was to explore the role of the SULF2-mediated ERK/AKT signaling pathway in cervical cancer. SULF2 expression was detected in tumor tissues and tumor-adjacent normal tissues from cervical cancer patients. HeLa… read more here.
Keywords: sulf2; erk akt; akt signaling; group ... See more keywords
Stathmin decreases cholangiocarcinoma cell line sensitivity to staurosporine-triggered apoptosis via the induction of ERK and Akt signaling
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.15005
Abstract: Cholangiocarcinoma is a rare, but highly fatal malignancy. However, the intrinsic mechanism involved in its tumorigenesis remains obscure. An urgent need remains for a promising target for cholangiocarcinoma biological therapies. Based on comparative proteomical technologies,… read more here.
Keywords: cell; apoptosis; erk akt; induction erk ... See more keywords
Vaccinium bracteatum Leaf Extract Reverses Chronic Restraint Stress-Induced Depression-Like Behavior in Mice: Regulation of Hypothalamic-Pituitary-Adrenal Axis, Serotonin Turnover Systems, and ERK/Akt Phosphorylation
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2018.00604
Abstract: The leaves of Vaccinium bracteatum Thunb. are a source of traditional herbal medicines found in East Asia. The present study aimed to evaluate the mechanisms underlying the antidepressant-like effects of water extract of V. bracteatum… read more here.
Keywords: serotonin turnover; erk akt; phosphorylation; bracteatum ... See more keywords
Marine Compound 3-Bromo-4,5-dihydroxybenzaldehyde Protects Skin Cells against Oxidative Damage via the Nrf2/HO-1 Pathway
Sign Up to like & getrecommendations! Published in 2019 at "Marine Drugs"
DOI: 10.3390/md17040234
Abstract: In this study, we aimed to illustrate the potential bio-effects of 3-bromo-4,5-dihydroxybenzaldehyde (3-BDB) on the antioxidant/cytoprotective enzyme heme oxygenase-1 (HO-1) in keratinocytes. The antioxidant effects of 3-BDB were examined via reverse transcription PCR, Western blotting,… read more here.
Keywords: marine compound; oxidative damage; erk akt; compound bromo ... See more keywords