Dammarane sapogenins attenuates stress‐induced anxiety‐like behaviors by upregulating ERK/CREB/BDNF pathways
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DOI: 10.1002/ptr.6713
Abstract: Dammarane sapogenins (DS), an extract derived from ginseng by alkaline hydrolysis of total ginsenosides, possesses high pharmacological activity and higher bioavailability than ginsenosides. The present study was designed to investigate the anxiolytic‐like effects of DS… read more here.
Keywords: creb bdnf; anxiety like; creb; erk creb ... See more keywords
Ginsenoside Rb1 attenuates methamphetamine (METH)-induced neurotoxicity through the NR2B/ERK/CREB/BDNF signalings in vitro and in vivo models
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Ginseng Research"
DOI: 10.1016/j.jgr.2021.07.005
Abstract: Abstract Aim This study investigates the effects of ginsenoside Rb1 (GsRb1) on methamphetamine (METH)-induced toxicity in SH-SY5Y neuroblastoma cells and METH-induced conditioned place preference (CPP) in adult Sprague-Dawley rats. It also examines whether GsRb1 can… read more here.
Keywords: nr2b erk; erk creb; creb bdnf; creb ... See more keywords
High fat induces activation of the tryptophan-ERK-CREB pathway and promotes bone absorption in cage layers
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DOI: 10.1016/j.psj.2021.101149
Abstract: Cage layer fatigue is a common metabolic disease associated with a calcium and phosphorus imbalance, but recently we found this disease can be led by high fat diet. In order to elucidate the pathogenesis induced… read more here.
Keywords: group; fat; bone; high fat ... See more keywords
Inosine alleviates depression-like behavior and increases the activity of the ERK-CREB signaling in adolescent male rats
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DOI: 10.1097/wnr.0000000000001101
Abstract: Inosine, a major breakdown product of adenosine by the enzyme adenosine deaminase, binds to adenosine receptors and initiates intracellular signaling events. Adenosine and inosine have already been described as capable of modulating depression-like behavior in… read more here.
Keywords: like behavior; inosine; erk creb; activity ... See more keywords
Mannosylerythritol lipids inhibit melanogenesis via suppressing ERK‐CREB‐MiTF‐tyrosinase signalling in normal human melanocytes and a three‐dimensional human skin equivalent
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DOI: 10.1111/exd.13836
Abstract: Hyperpigmentation is caused by excessive production of melanin in melanocytes. Mannosylerythritol lipids (MELs) are glycolipid biosurfactants that are abundantly produced by yeasts and used commercially in cosmetics. However, the potential depigmenting efficacy of MELs has… read more here.
Keywords: skin equivalent; human skin; normal human; human melanocytes ... See more keywords
Yuk-Gunja-Tang attenuates neuronal death and memory impairment via ERK/CREB/BDNF signaling in the hippocampi of experimental Alzheimer’s disease model
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1014840
Abstract: Yuk-Gunja-Tang (YG) is the Korean traditional medicine in East Asia for gastrointestinal disorders. In the present study, we determined the protective effects of YG on glutamate-induced cytotoxicity in HT22 hippocampal neuronal cells and mice with… read more here.
Keywords: memory; erk creb; expression; memory impairment ... See more keywords
Paeoniflorin Ameliorates Chronic Stress-Induced Depression-Like Behaviors and Neuronal Damages in Rats via Activation of the ERK-CREB Pathway
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2018.00772
Abstract: Neuronal damage is related to the onset and treatment of depressive disorders. Antidepressant-like effects have been elicited by paeoniflorin on animal models. The aim of this study is to demonstrate whether the neuroprotective effect of… read more here.
Keywords: paeoniflorin ameliorates; creb; stress; pathway ... See more keywords