LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "erk dependent" as a keyword



Photo by ornarin from unsplash

TSC2/Rheb signaling mediates ERK‐dependent regulation of mTORC1 activity in C2C12 myoblasts

Sign Up to like & get
recommendations! Published in 2017 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12195

Abstract: The enhanced rate of protein synthesis in skeletal muscle cells results in a net increase in total protein content that leads to skeletal muscle growth/hypertrophy. The mitogen‐activated protein kinase kinase (MEK)/extracellular signal‐regulated kinase (ERK)‐dependent regulation… read more here.

Keywords: c2c12 myoblasts; mtorc1; activation; erk dependent ... See more keywords

Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers

Sign Up to like & get
recommendations! Published in 2024 at "Science"

DOI: 10.1126/science.adk0775

Abstract: How the KRAS oncogene drives cancer growth remains poorly understood. Therefore, we established a systemwide portrait of KRAS- and extracellular signal–regulated kinase (ERK)–dependent gene transcription in KRAS-mutant cancer to delineate the molecular mechanisms of growth… read more here.

Keywords: cancer; erk dependent; kras mutant; kras erk ... See more keywords

Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer

Sign Up to like & get
recommendations! Published in 2024 at "Science"

DOI: 10.1126/science.adk0850

Abstract: To delineate the mechanisms by which the ERK1 and ERK2 mitogen-activated protein kinases support mutant KRAS–driven cancer growth, we determined the ERK-dependent phosphoproteome in KRAS-mutant pancreatic cancer. We determined that ERK1 and ERK2 share near-identical… read more here.

Keywords: cancer; erk dependent; kinase; kras mutant ... See more keywords

RNF144a induces ERK-dependent cell death under oxidative stress via downregulation of Vaccinia Related Kinase3.

Sign Up to like & get
recommendations! Published in 2020 at "Journal of cell science"

DOI: 10.1242/jcs.247304

Abstract: Vaccinia-related kinase 3 (VRK3) has been reported to be a negative regulator of ERK that protects cells from persistent ERK activation and inhibits ERK dependent apoptosis. Here we report that the E3 ligase, RNF144a, promotes… read more here.

Keywords: vrk3; rnf144a; erk dependent; vaccinia related ... See more keywords