Diterbutyl phthalate attenuates osteoarthritis in ACLT mice via suppressing ERK/c-fos/NFATc1 pathway, and subsequently inhibiting subchondral osteoclast fusion.
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DOI: 10.1038/s41401-021-00747-9
Abstract: Osteoarthritis (OA) is the most common arthritis with a rapidly increasing prevalence. Disease progression is irreversible, and there is no curative therapy available. During OA onset, abnormal mechanical loading leads to excessive osteoclastogenesis and bone… read more here.
Keywords: osteoclast fusion; erk fos; subchondral bone; diterbutyl phthalate ... See more keywords