c-Jun-mediated JMJD6 restoration enhances resistance of liver cancer to radiotherapy through the IL-4-activated ERK pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Cell biology international"
DOI: 10.1002/cbin.12026
Abstract: Radiotherapy is widely used in the treatment of liver cancer, but the efficacy can be limited by radioresistance. In this study, we attempt to delineate the possible molecular mechanism of c-Jun-regulated Jumonji domain-containing protein 6/interleukin… read more here.
Keywords: erk pathway; liver cancer; jun; resistance ... See more keywords
MAPK/ERK pathway inhibition is a promising treatment target for adrenocortical tumors
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27451
Abstract: Unraveling molecular mechanisms that regulate tumor development and proliferation is of the utmost importance in the quest to decrease the high mortality rate of adrenocortical carcinomas (ACC). Our aim was to evaluate the role of… read more here.
Keywords: pathway inhibition; treatment; mapk; erk pathway ... See more keywords
TRIM59, amplified in ovarian cancer, promotes tumorigenesis through the MKP3/ERK pathway
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29478
Abstract: Tripartite motif containing 59 (TRIM59) functions as an oncoprotein in various human cancers including ovarian cancer. In this study, we found that TRIM59 gene amplification was prevalent in ovarian cancer tissues, and its amplification was… read more here.
Keywords: trim59; mkp3 erk; ovarian cancer; erk pathway ... See more keywords
Triphenyl phosphate-induced macrophages dysfunction by activation TLR4-mediated ERK/NF-κB pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental toxicology"
DOI: 10.1002/tox.23778
Abstract: Triphenyl phosphate (TPHP) is one of the most widely used organic phosphorus flame retardants and is ubiquitous in the environment. Studies have been reported that TPHP may lead to obesity, neurotoxicity and reproductive toxicity, but… read more here.
Keywords: erk pathway; triphenyl phosphate; tlr4 mediated; mediated erk ... See more keywords
Dexmedetomidine Relieves Acute Inflammatory Visceral Pain in Rats through the ERK Pathway, Toll-Like Receptor Signaling, and TRPV1 Channel
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-018-1172-5
Abstract: Dexmedetomidine (DEX) is a highly selective α2 adrenergic receptor agonist. In this study, we aimed to characterize the antinociceptive effects of DEX in acute inflammatory visceral pain (AIVP) induced by acetic acid in rats and… read more here.
Keywords: acute inflammatory; dex; trpv1 channel; erk pathway ... See more keywords
The ERK Pathway: Molecular Mechanisms and Treatment of Depression
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-1524-3
Abstract: Major depressive disorder is a chronic debilitating mental illness. Its pathophysiology at cellular and molecular levels is incompletely understood. Increasing evidence supports a pivotal role of the mitogen-activated protein kinase (MAPK), in particular the extracellular… read more here.
Keywords: depression; erk; treatment depression; erk pathway ... See more keywords
Lipin1 mediates cognitive impairment in fld mice via PKD-ERK pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.02.070
Abstract: Lipin1 is important in lipid synthesis because of its phosphatidate phosphatase activity, and it also functions as transcriptional coactivators to regulate the expression of genes involved in lipid metabolism. We found that fld mice exhibit… read more here.
Keywords: pkd erk; cognitive impairment; mice; erk pathway ... See more keywords
A flibercept regulates retinal inflammation elicited by high glucose via the PlGF/ERK pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.07.021
Abstract: Diabetic retinopathy (DR) is a secondary complication of diabetes. DR can cause irreversible blindness, and its pathogenesis has been considered multifactorial. DR can progress from non-proliferative DR to proliferative DR, characterized by retinal neovascularization. The… read more here.
Keywords: aflibercept anti; retinal inflammation; plgf; flibercept regulates ... See more keywords
&bgr;2‐receptor agonists salbutamol and terbutaline attenuated cytokine production by suppressing ERK pathway through cAMP in macrophages
Sign Up to like & getrecommendations! Published in 2017 at "Cytokine"
DOI: 10.1016/j.cyto.2016.07.016
Abstract: HighlightsIn general, ligand‐&bgr;2‐receptor engagement activates ERK pathway.In this study, &bgr;2‐agonists inhibited TNF and MCP‐1 production in macrophages.Inhibition of TNF and MCP‐1 production was associated with attenuated ERK signaling.Suppression of ERK pathway was dependent on cAMP… read more here.
Keywords: production; camp; receptor agonists; bgr receptor ... See more keywords
ERK pathway activation contributes to the tumor-promoting effects of hepatic stellate cells in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2017 at "Immunology letters"
DOI: 10.1016/j.imlet.2017.06.009
Abstract: BACKGROUND Activated hepatic stellate cell (aHSC) play a critical role in hepatocellular carcinoma (HCC) progression crosstalking with cancer cell via various signaling pathways. The aim of our study is to explore the tumor-promoting effects of… read more here.
Keywords: hepatocellular carcinoma; hcc; hcc cells; expression ... See more keywords
NGF protects against oxygen and glucose deprivation-induced oxidative stress and apoptosis by up-regulation of HO-1 through MEK/ERK pathway
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.01.046
Abstract: Both nerve growth factor (NGF) and heme oxygenases-1 (HO-1) promotes neuron survival from cerebral ischemic lesions. NGF protects neurons from oxygen-glucose deprivation (OGD), and HO-1 expression can be induced by some growth factors like NGF.… read more here.
Keywords: mek erk; ngf protects; apoptosis; glucose deprivation ... See more keywords