Lidocaine inhibits melanoma cell proliferation by regulating ERK phosphorylation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27927
Abstract: The melanoma is responsible for the majority of all skin cancer–related deaths worldwide. Evidence suggests that local anesthetics provide some benefit in the treatment of cancer via inhibition of cellular proliferation, invasion and migration. However,… read more here.
Keywords: melanoma cell; erk phosphorylation; cell proliferation; proliferation ... See more keywords
Inhibition of basal and amphetamine-stimulated extracellular signal-regulated kinase (ERK) phosphorylation in the rat forebrain by muscarinic acetylcholine M4 receptors
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research"
DOI: 10.1016/j.brainres.2018.03.019
Abstract: The mitogen-activated protein kinase (MAPK), especially its extracellular signal-regulated kinase (ERK) subfamily, is a group of kinases enriched in the mammalian brain. While ERK is central to cell signaling and neural activities, the regulation of… read more here.
Keywords: amphetamine; acetylcholine; erk phosphorylation; kinase ... See more keywords
Enhancement of ERK phosphorylation and photic responses in Vc/C1 neurons of a migraine model
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.03.023
Abstract: Although it is well known that migraine pain is enhanced by photic stimulation of the eye, the mechanisms underlying this response are not yet understood. Noxious stimulation to the dura is known to activate trigeminal… read more here.
Keywords: erk phosphorylation; stimulation; migraine pain; photic stimulation ... See more keywords
The testosterone metabolite 3α-androstanediol inhibits oxidative stress-induced ERK phosphorylation and neurotoxicity in SH-SY5Y cells through an MKP3/DUSP6-dependent mechanism
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.12.012
Abstract: Testosterone exerts neuroprotective effects on the brain, but the mechanisms by which these effects are exerted appear to be different in males and females. While in females they involve local conversion to estradiol, in males… read more here.
Keywords: oxidative stress; phosphorylation; erk phosphorylation; mkp3 dusp6 ... See more keywords
Levo-tetrahydropalmatine attenuates methamphetamine reward behavior and the accompanying activation of ERK phosphorylation in mice
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2019.134416
Abstract: Levo-tetrahydropalmatine (L-THP) is the main active ingredient of traditional Chinese herbal medicine Corydalis and Stephania, which have been used for sedative, neuroleptic, and analgesic purposes. Previous studies have demonstrated that L-THP has antagonistic activation on… read more here.
Keywords: thp; reward behavior; erk phosphorylation; group ... See more keywords
Ageing causes an aortic contractile dysfunction phenotype by targeting the expression of members of the extracellular signal‐regulated kinase pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17118
Abstract: The extracellular signal‐regulated kinase (ERK) pathway is a well‐known regulator of vascular smooth muscle cell proliferation, but it also serves as a regulator of caldesmon, which negatively regulates vascular contractility. This study examined whether aortic… read more here.
Keywords: erk phosphorylation; aortic contractile; extracellular signal; expression ... See more keywords
PO-476 Increased ERK phosphorylation as a candidate driver of resistance to the experimental cancer drug AT13148
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.495
Abstract: Introduction The AGC family of serine/threonine protein kinases comprises a number of drug targets with therapeutic potential for the treatment of cancer. AT13148 is an ATP competitive AGC kinase inhibitor, currently in phase 1 clinical… read more here.
Keywords: erk phosphorylation; drug; resistance; cancer ... See more keywords
hucMSC-Ex Alleviates IBD-Associated Intestinal Fibrosis by Inhibiting ERK Phosphorylation in Intestinal Fibroblasts
Sign Up to like & getrecommendations! Published in 2023 at "Stem Cells International"
DOI: 10.1155/2023/2828981
Abstract: Background Intestinal fibrosis, one of the complications of inflammatory bowel disease (IBD), is associated with fistula and intestinal stricture formation. There are currently no treatments for fibrosis. Mesenchymal stem cell-derived exosomes have been proven to… read more here.
Keywords: intestinal fibroblasts; ibd associated; erk phosphorylation; intestinal fibrosis ... See more keywords
6-O-angeloylplenolin inhibits anti-IgE-stimulated human mast cell activation via suppressing calcium influx and ERK phosphorylation
Sign Up to like & getrecommendations! Published in 2022 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2022.64132.14120
Abstract: Objective(s): Mast cells are important immune cells that primarily localize in the interface between the host and external environment, and protect us from pathogen infection. However, they are also involved in the pathology of allergic… read more here.
Keywords: calcium; erk phosphorylation; mast; influx erk ... See more keywords
Prostaglandin F2α Regulates Adipogenesis by Modulating Extracellular Signal-Regulated Kinase Signaling in Graves’ Ophthalmopathy
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24087012
Abstract: Prostaglandin F2α (PGF2α), the first-line anti-glaucoma medication, can cause the deepening of the upper eyelid sulcus due to orbital lipoatrophy. However, the pathogenesis of Graves’ ophthalmopathy (GO) involves the excessive adipogenesis of the orbital tissues.… read more here.
Keywords: graves ophthalmopathy; erk phosphorylation; extracellular signal; phosphorylation ... See more keywords
Reduction in Insulin Mediated ERK Phosphorylation by Palmitate in Liver Cells Is Independent of Fatty Acid Induced ER Stress
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu14173641
Abstract: Saturated free fatty acids (FFAs) such as palmitate in the circulation are known to cause endoplasmic reticulum (ER) stress and insulin resistance in peripheral tissues. In addition to protein kinase B (AKT) signaling, extracellular signal-regulated… read more here.
Keywords: stress; erk phosphorylation; palmitate; insulin mediated ... See more keywords