Fibroblast growth factor 9 activates anti‐oxidative functions of Nrf2 through ERK signalling in striatal cell models of Huntington's disease
Sign Up to like & getrecommendations! Published in 2019 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.455
Abstract: ABSTRACT Huntington's disease (HD) is a heritable neurodegenerative disorder, and has been characterized as an increase of oxidative stress in brain regions. In our previous results, we showed fibroblast growth factor 9 (FGF9) provides neuroprotective… read more here.
Keywords: stress; anti oxidative; erk signalling; factor ... See more keywords
SHANK3 depletion leads to ERK signalling overdose and cell death in KRAS-mutant cancers
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-52326-1
Abstract: The KRAS oncogene drives many common and highly fatal malignancies. These include pancreatic, lung, and colorectal cancer, where various activating KRAS mutations have made the development of KRAS inhibitors difficult. Here we identify the scaffold… read more here.
Keywords: mapk erk; erk signalling; shank3; depletion ... See more keywords
Suppression of ERK signalling promotes pluripotent epiblast in the human blastocyst
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-61830-x
Abstract: Studies in the mouse demonstrate the importance of fibroblast growth factor (FGF) and extra-cellular receptor tyrosine kinase (ERK) in specification of embryo-fated epiblast and yolk-sac-fated hypoblast cells from uncommitted inner cell mass (ICM) cells prior… read more here.
Keywords: promotes pluripotent; blastocyst; signalling promotes; erk signalling ... See more keywords
RUNX2 mutation inhibits the cellular senescence of dental follicle cells via ERK signalling pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Oral diseases"
DOI: 10.1111/odi.14607
Abstract: OBJECTIVE The aim of this study was to explore the regulatory effect of RUNX2 mutation on dental follicle cells (DFCs) senescence and clarify the underlying mechanism. This study aimed to explore the basis for a… read more here.
Keywords: dfcs senescence; erk signalling; senescence; runx2 mutation ... See more keywords
TLQP-21 is a low potency partial C3aR activator on human primary macrophages
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1086673
Abstract: TLQP-21 is a 21-amino acid neuropeptide derived from the VGF precursor protein. TLQP-21 is expressed in the nervous system and neuroendocrine glands, and demonstrates pleiotropic roles including regulating metabolism, nociception and microglial functions. Several possible… read more here.
Keywords: erk signalling; potency; tlqp; tlqp low ... See more keywords
The Modulation of Immune Responses in Tilapinevirus tilapiae-Infected Fish Cells through MAPK/ERK Signalling
Sign Up to like & getrecommendations! Published in 2023 at "Viruses"
DOI: 10.3390/v15040900
Abstract: Tilapia lake virus (TiLV) is a novel RNA virus that has been causing substantial economic losses across the global tilapia industry. Despite extensive research on potential vaccines and disease control methods, the understanding of this… read more here.
Keywords: erk signalling; tilv infection; infection; tib cells ... See more keywords