Extracellular signal-regulated kinase 1/2 regulates NAD metabolism during acute kidney injury through microRNA-34a-mediated NAMPT expression
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DOI: 10.1007/s00018-019-03391-z
Abstract: Prior studies have established the important role of extracellular signal-regulated kinase 1/2 (ERK1/2) as a mediator of acute kidney injury (AKI). We demonstrated rapid ERK1/2 activation induced renal dysfunction following ischemia/reperfusion (IR)-induced AKI and downregulated… read more here.
Keywords: inhibition; erk1 activation; extracellular signal; activation ... See more keywords
Cannabidiol induces autophagy via ERK1/2 activation in neural cells
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DOI: 10.1038/s41598-021-84879-2
Abstract: Autophagy is a lysosomal catabolic process essential to cell homeostasis and is related to the neuroprotection of the central nervous system. Cannabidiol (CBD) is a non-psychotropic phytocannabinoid present in Cannabis sativa. Many therapeutic actions have… read more here.
Keywords: autophagy via; erk1 activation; induces autophagy; cannabidiol induces ... See more keywords
MAS1 Receptor Trafficking Involves ERK1/2 Activation Through a &bgr;-Arrestin2–Dependent Pathway
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DOI: 10.1161/hypertensionaha.117.09789
Abstract: The MAS1 receptor (R) exerts protective effects in the brain, heart, vessels, and kidney. R trafficking plays a critical function in signal termination and propagation and in R resensitization. We examined MAS1R internalization and trafficking… read more here.
Keywords: stimulation; bgr arrestin2; erk1 activation; activation ... See more keywords