High glucose-induced ROS accumulation is a critical regulator of ERK1/2-Akt-tuberin-mTOR signalling in RGC-5 cells.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117914
Abstract: Hyperglycemia and oxidative stress are the primary stressors that elicit mitochondria specific cell stress in diabetes. Here we hypothesized that elevated level of ROS in high glucose (HG) environment, trigger mitochondrial stress by damaging mitochondrial… read more here.
Keywords: tuberin mtor; erk1 akt; akt tuberin; tuberin ... See more keywords
BDNF promoted osteoblast migration and fracture healing by up‐regulating integrin β1 via TrkB‐mediated ERK1/2 and AKT signalling
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DOI: 10.1111/jcmm.15704
Abstract: Brain‐derived neurotrophic factor (BDNF) has been reported to participate in fracture healing, whereas the mechanism is still unclear. Since osteoblast migration is important for fracture healing, investigating effects of BDNF on osteoblasts migration may help… read more here.
Keywords: erk1 akt; fracture; trkb; migration ... See more keywords
Single serine on TSC2 exerts biased control over mTORC1 activation mediated by ERK1/2 but not Akt
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DOI: 10.26508/lsa.202101169
Abstract: Both ERK1/2 and Akt kinases activate mTORC1, but only the former is bidirectionally regulated by the status of serine S1364 on TSC2 that confers input-selective mTORC1 amplification or attenuation. read more here.
Keywords: tsc2; akt; single serine; mtorc1 ... See more keywords
β-Hydroxybutyrate inhibits apoptosis in bovine neutrophils through activating ERK1/2 and AKT signaling pathways.
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DOI: 10.3168/jds.2021-21259
Abstract: Ketosis in dairy cows, a common metabolic disorder during the peripartal period, is accompanied by systemic inflammation and high concentrations of blood β-hydroxybutyrate (BHB). Neutrophil apoptosis plays a key role in maintaining the balance of… read more here.
Keywords: apoptosis; bovine neutrophils; akt signaling; bhb ... See more keywords
Modulation of ERK1/2 and Akt Pathways Involved in the Neurotrophic Action of Caffeic Acid Alkyl Esters
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DOI: 10.3390/molecules23123340
Abstract: Neurodegenerative diseases affect millions of human lives all over the world. The number of afflicted patients is rapidly growing, and disease-modifying agents are urgently needed. Caffeic acid, an important member of the hydroxycinnamic acid family… read more here.
Keywords: caffeic acid; modulation erk1; neurotrophic action; erk1 akt ... See more keywords