ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1
Sign Up to like & getrecommendations! Published in 2023 at "Biochemical Journal"
DOI: 10.1042/bcj20220598
Abstract: Innate or acquired resistance to small molecule BRAF or MEK1/2 inhibitors (BRAFi or MEKi) typically arises through mechanisms that sustain or reinstate ERK1/2 activation. This has led to the development of a range of ERK1/2… read more here.
Keywords: turnover erk2; proteasome dependent; erk1; erk1 inhibitors ... See more keywords