Biglycan, a Nitric Oxide-Downregulated Proteoglycan, Prevents Nitric Oxide-Induced Neuronal Cell Apoptosis via Targeting Erk1/2 and p38 Signaling Pathways
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-018-1151-x
Abstract: Nitric oxide (NO), a gaseous signaling molecule, induces apoptosis and mediates neurodegenerative diseases and brain injury. Biglycan (BGN), a member of the small leucine-rich proteoglycan family, was demonstrated to exert anti-apoptosis function in various disease… read more here.
Keywords: cell; apoptosis; bgn; nitric oxide ... See more keywords
Hyperglycemia‐impaired aortic vasorelaxation mediated through arginase elevation: Role of stress kinase pathways
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.11.027
Abstract: &NA; Diabetes‐induced vascular endothelial dysfunction has been reported to involve hyperglycemia‐induced increases in arginase activity. However, upstream mediators of this effect are not clear. Here, we have tested involvement of Rho kinase, ERK1/2 and p38… read more here.
Keywords: p38 mapk; impaired aortic; arginase activity; arg1 ... See more keywords
Hydrogen sulfide primes diabetic wound to close through inhibition of NETosis
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2018.10.013
Abstract: Diabetes-induced neutrophil NETosis impairs wound healing through neutrophil extracellular traps (NETs). Reactive oxygen species (ROS)-triggered activation of mitogen-activated protein kinase (MAPK) ERK1/2 and p38 is involved in NETosis. Hydrogen sulfide (H2S), an endogenous signaling molecule,… read more here.
Keywords: netosis; activation; diabetic wound; erk1 p38 ... See more keywords
ERK potentiates p38 in central sensitization induced by traumatic occlusion
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DOI: 10.1016/j.neuroscience.2016.11.012
Abstract: This study was to investigate the role of p38 activation via ERK1/2 phosphorylation in neurons and microglia of the spinal trigeminal subnucleus caudalis (Vc) in the promotion of orofacial hyperalgesia induced by unilateral anterior crossbite… read more here.
Keywords: central sensitization; hyperalgesia; p38; traumatic occlusion ... See more keywords
αCGRP Regulates Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells Through ERK1/2 and p38 MAPK Signaling Pathways
Sign Up to like & getrecommendations! Published in 2022 at "Cell Transplantation"
DOI: 10.1177/09636897221107636
Abstract: As a typical neuropeptide richly distributed in central and peripheral nervous systems, α-calcitonin-gene-related peptide (αCGRP) has recently been found to play a crucial role in bone development and metabolism, but the mechanisms involved are not… read more here.
Keywords: cgrp; mapk signaling; osteogenic differentiation; p38 mapk ... See more keywords
Icariin induces cell differentiation and cell cycle arrest in mouse melanoma B16 cells via Erk1/2-p38-JNK-dependent pathway
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.20118
Abstract: Icariin (ICA) is a major component isolated from Epimedium brevicornum. Emerging evidence shows that ICA can inhibit tumor cell proliferation, invasion and migration. However, the anti-cancer effect of ICA on B16 cells has not been… read more here.
Keywords: p38 jnk; b16; cell; erk1 p38 ... See more keywords
Nisin Z attenuates lipopolysaccharide-induced mastitis by inhibiting the ERK1/2 and p38 mitogen-activated protein kinase signaling pathways.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of dairy science"
DOI: 10.3168/jds.2021-21356
Abstract: Nisin Z is a possible alternative for treating bovine mastitis by inhibiting mastitis-causing pathogens and having anti-inflammatory activity. However, the anti-inflammatory mechanism of nisin Z on mastitis is unknown. Our study aimed to investigate the… read more here.
Keywords: induced mastitis; mastitis; anti inflammatory; mastitis inhibiting ... See more keywords
Central Kisspeptin Does Not Affect ERK1/2 or p38 Phosphorylation in Oxytocin Neurons of Late-Pregnant Rats
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23147729
Abstract: Oxytocin is secreted by hypothalamic supraoptic nucleus (SON) and paraventricular nucleus (PVN) oxytocin neurons to induce uterine contractions during parturition. Increased activation of oxytocin neurons at parturition involves a network of afferent inputs that increase… read more here.
Keywords: pregnant rats; neurons late; oxytocin neurons; late pregnant ... See more keywords