Methyl helicterate inhibits hepatic stellate cell activation through downregulating the ERK1/2 signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28756
Abstract: The present study was to investigate the inhibitory effect of methyl helicterate (MH) on hepatic stellate cells (HSC‐T6), primarily elucidating the underlying mechanism of MH against liver fibrosis. HSC‐T6 cells were activated by platelet‐derived growth… read more here.
Keywords: methyl helicterate; signaling pathway; activation; cell ... See more keywords
Reduced LINC00467 elevates microRNA-125a-3p to suppress cisplatin resistance in non-small cell lung cancer through inhibiting sirtuin 6 and inactivating the ERK1/2 signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Cell biology and toxicology"
DOI: 10.1007/s10565-021-09637-6
Abstract: OBJECTIVE The non-coding RNAs have been identified as potential biomarkers in cancers. This study aimed to investigate the effect of long intergenic non-protein coding RNA 467 (LINC00467)/microRNA (miR-125a-3p)/sirtuin 6 (SIRT6) axis on non-small cell lung… read more here.
Keywords: sirt6; signaling pathway; resistance; mir 125a ... See more keywords
Characteristic ERK1/2 signaling dynamics distinguishes necroptosis from apoptosis
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.103074
Abstract: Summary ERK1/2 involvement in cell death remains unclear, although many studies have demonstrated the importance of ERK1/2 dynamics in determining cellular responses. To untangle how ERK1/2 contributes to two cell death programs, we investigated ERK1/2… read more here.
Keywords: apoptosis; necroptosis; erk1; signaling dynamics ... See more keywords
Nano-Hydroxyapatite Stimulation of Gene Expression Requires Fgf Receptor, Phosphate Transporter, and Erk1/2 Signaling.
Sign Up to like & getrecommendations! Published in 2017 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.7b12029
Abstract: Hydroxyapatite (HAp) is critical to health both as the main structural material of the skeleton and storage material of calcium and phosphate. Nanosized HAp (nHAp) is naturally produced by mineralizing cells during bone formation and… read more here.
Keywords: gene expression; receptor; gene; erk1 signaling ... See more keywords
ERK1/2 Signaling Induces Upregulation of ANGPT2 and CXCR4 to Mediate Liver Metastasis in Colon Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/0008-5472.can-19-4028
Abstract: These findings identify amplified ERK1/2 signaling in KRAS-mutated colorectal cancer cells as a driver of tumor–stroma interactions that favor formation of metastases in the liver. Carcinoma development in colorectal cancer is driven by genetic alterations… read more here.
Keywords: metastasis; cancer cells; cancer; angpt2 cxcr4 ... See more keywords
ALPK1 Aggravates TMJOA Cartilage Degradation via NF-κB and ERK1/2 Signaling
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Dental Research"
DOI: 10.1177/00220345221100179
Abstract: Temporomandibular joint osteoarthritis (TMJOA) is a common degenerative joint disease without effective intervention strategies. Previous research implied that alpha-kinase 1 (ALPK1) is involved in the inflammatory responses of gout, a chronic arthritis. Herein, we found… read more here.
Keywords: erk1 signaling; pathology; alpk1; condylar cartilage ... See more keywords
Ras-ERK1/2 signaling contributes to the development of colorectal cancer via regulating H3K9ac
Sign Up to like & getrecommendations! Published in 2018 at "BMC Cancer"
DOI: 10.1186/s12885-018-5199-3
Abstract: Backgrounds/aimsRas is a control switch of ERK1/2 pathway, and hyperactivation of Ras-ERK1/2 signaling appears frequently in human cancers. However, the molecular regulation following by Ras-ERK1/2 activation is still unclear. This work aimed to reveal whether… read more here.
Keywords: development colorectal; colorectal cancer; h3k9ac; erk1 signaling ... See more keywords
Receptor Type Protein Tyrosine Phosphatase Epsilon (PTPRE) Plays an Oncogenic Role in Thyroid Carcinoma by Activating the AKT and ERK1/2 Signaling Pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Current cancer drug targets"
DOI: 10.2174/1568009623666230118111745
Abstract: BACKGROUND Thyroid carcinoma (TC) is a common malignant tumor in human and its incidence has been increasing in recent years. Studies have shown that receptor type protein tyrosine phosphatase epsilon (PTPRE) is a key regulator… read more here.
Keywords: thyroid carcinoma; signaling pathway; erk1 signaling; role ... See more keywords
Sprouty4 at the crossroads of Trk neurotrophin receptor signaling suppression by glucocorticoids
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2023.1090824
Abstract: Glucocorticoids (GC) affect neuronal plasticity, development and function of the nervous system by inhibiting neurotrophin-induced Trk signaling. It has been established that pretreatment with dexamethasone (DEX) restricts Neurotrophin-induced neurite outgrowth by inhibiting Trk-dependent activation of… read more here.
Keywords: sprouty4 crossroads; sprouty4; erk1 signaling; crossroads trk ... See more keywords
17β-Estradiol Enhances Schwann Cell Differentiation via the ERβ-ERK1/2 Signaling Pathway and Promotes Remyelination in Injured Sciatic Nerves
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2018.01026
Abstract: Remyelination is critical for nerve regeneration. However, the molecular mechanism involved in remyelination is poorly understood. To explore the roles of 17β-estradiol (E2) for myelination in the peripheral nervous system, we used a co-culture model… read more here.
Keywords: promotes remyelination; differentiation; sciatic nerves; erk1 signaling ... See more keywords
Ameliorative Effects of Osthole on Experimental Renal Fibrosis in vivo and in vitro by Inhibiting IL-11/ERK1/2 Signaling
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.646331
Abstract: Objectives: Natural product, osthole, has been proven to have a protective effect on organ fibrosis, including renal fibrosis. All of these studies are mainly focused on the regulation of TGF-β/Smad signaling pathway. However, due to… read more here.
Keywords: fibrosis; effects osthole; signaling pathway; tgf ... See more keywords