RafâERK1/2 signalling pathways mediate steroid hormone synthesis in bovine ovarian granulosa cells
Sign Up to like & getrecommendations! Published in 2019 at "Reproduction in Domestic Animals"
DOI: 10.1111/rda.13419
Abstract: Steroid hormones are required for normal reproductive function of female. The aim of this study was to investigate the role of Raf-ERK1/2 on steroid hormone synthesis in bovine ovarian granulosa cells. Immunohistochemistry assay showed that… read more here.
Keywords: granulosa cells; steroid hormone; hormone synthesis; raf erk1 ... See more keywords
ERK1/2 signalling dynamics promote neural differentiation by regulating chromatin accessibility and the polycomb repressive complex
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DOI: 10.1371/journal.pbio.3000221
Abstract: Fibroblast growth factor (FGF) is a neural inducer in many vertebrate embryos, but how it regulates chromatin organization to coordinate the activation of neural genes is unclear. Moreover, for differentiation to progress, FGF signalling must… read more here.
Keywords: erk1 signalling; polycomb; repressive complex; differentiation ... See more keywords
ERK5 Signalling and Resistance to ERK1/2 Pathway Therapeutics: The Path Less Travelled?
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DOI: 10.3389/fcell.2022.839997
Abstract: The RAS-regulated RAF-MEK1/2-ERK1/2 signalling pathway is frequently de-regulated in human cancer. Melanoma in particular exhibits a high incidence of activating BRAFV600E/K and NRASQ61L/K mutations and such cells are addicted to the activity of these mutant… read more here.
Keywords: erk1 signalling; signalling resistance; erk5 signalling; erk1 ... See more keywords
ERK1,2 Signalling Pathway along the Nephron and Its Role in Acid-base and Electrolytes Balance
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DOI: 10.3390/ijms20174153
Abstract: Mitogen-activated protein kinases (MAPKs) are intracellular molecules regulating a wide range of cellular functions, including proliferation, differentiation, apoptosis, cytoskeleton remodeling and cytokine production. MAPK activity has been shown in normal kidney, and its over-activation has… read more here.
Keywords: base electrolytes; acid base; erk1 signalling; signalling pathway ... See more keywords