Functional divergence caused by mutations in an energetic hotspot in ERK2
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DOI: 10.2210/pdb6ots/pdb
Abstract: The most frequent extracellular signal-regulated kinase 2 (ERK2) mutation occurring in cancers is E322K (E-K). ERK2 E-K reverses a buried charge in the ERK2 common docking (CD) site, a region that binds activators, inhibitors, and… read more here.
Keywords: functional divergence; site; divergence caused; erk2 ... See more keywords