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   Articles with "erk2" as a keyword



Heme oxygenase-1 is an equid alphaherpesvirus 8 replication restriction host protein and suppresses viral replication via the PKCĪ²/ERK1/ERK2 and NO/cGMP/PKG pathway

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recommendations! Published in 2024 at "Microbiology Spectrum"

DOI: 10.1128/spectrum.03220-23

Abstract: ABSTRACT Equid alphaherpesvirus 8 (EqHV-8) is one of the most economically important viruses that is known to cause severe respiratory disease, abortion, and neurological syndromes in equines. However, no effective vaccines or therapeutic agents are… read more here.

Keywords: replication; cgmp; infection; erk2 ... See more keywords

Functional divergence caused by mutations in an energetic hotspot in ERK2

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recommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.2210/pdb6ots/pdb

Abstract: The most frequent extracellular signal-regulated kinase 2 (ERK2) mutation occurring in cancers is E322K (E-K). ERK2 E-K reverses a buried charge in the ERK2 common docking (CD) site, a region that binds activators, inhibitors, and… read more here.

Keywords: functional divergence; site; divergence caused; erk2 ... See more keywords

Conformation selection by ATP-competitive inhibitors and allosteric communication in ERK2

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recommendations! Published in 2024 at "eLife"

DOI: 10.7554/elife.91507

Abstract: Activation of the extracellular signal-regulated kinase-2 (ERK2) by phosphorylation has been shown to involve changes in protein dynamics, as determined by hydrogen-deuterium exchange mass spectrometry (HDX-MS) and NMR relaxation dispersion measurements. These can be described… read more here.

Keywords: atp competitive; activation; erk2; kinase ... See more keywords