Overexpression of TRAF4 promotes lung cancer growth and EGFR‐dependent phosphorylation of ERK5
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13458
Abstract: Tumor necrosis factor receptor‐associated factor 4 (TRAF4) is overexpressed in a variety of carcinomas of different origins, but its role in tumorigenesis remains incompletely understood. Previous studies suggest that TRAF4 promotes epidermal growth factor receptor… read more here.
Keywords: lung cancer; kinase; phosphorylation erk5; traf4 promotes ... See more keywords
Modulation of ERK5 Activity as a Therapeutic Anti-Cancer Strategy.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.3c00072
Abstract: The extracellular signal-regulated kinase 5 (ERK5) signaling pathway is one of four conventional mitogen-activated protein (MAP) kinase pathways. Genetic perturbation of ERK5 has suggested that modulation of ERK5 activity may have therapeutic potential in cancer… read more here.
Keywords: cancer; modulation; modulation erk5; erk5 ... See more keywords
Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2- d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01606
Abstract: The availability of a chemical probe to study the role of a specific domain of a protein in a concentration- and time-dependent manner is of high value. Herein, we report the identification of a highly… read more here.
Keywords: bay 885; probe; potent highly; characterization potent ... See more keywords
ERK5 is activated by oncogenic BRAF and promotes melanoma growth
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0164-9
Abstract: Malignant melanoma is among the most aggressive cancers and its incidence is increasing worldwide. Targeted therapies and immunotherapy have improved the survival of patients with metastatic melanoma in the last few years; however, available treatments… read more here.
Keywords: melanoma; melanoma growth; braf; oncogenic braf ... See more keywords
Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1707929115
Abstract: Significance Macrophages can be functionally reprogrammed by the tumor microenvironment to further tumor growth and malignancy. In this study, we have discovered that this pathological process is dependent on the ERK5 MAPK. Accordingly, we demonstrated… read more here.
Keywords: erk5; protumor macrophage; macrophage; tumor growth ... See more keywords
Platelet TLR4-ERK5 Axis Facilitates NET-Mediated Capturing of Circulating Tumor Cells and Distant Metastasis after Surgical Stress
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Research"
DOI: 10.1158/0008-5472.can-20-3222
Abstract: Targeting platelet activation via TLR4/ERK5/integrin GPIIb/IIIa signaling shows potential for preventing NET-driven distant metastasis in patients post-resection. Surgical removal of malignant tumors is a mainstay in controlling most solid cancers. However, surgical insult also increases… read more here.
Keywords: metastasis; erk5; tumor; platelet ... See more keywords
Abstract 5866: Discovery and profiling of a highly potent and selective ERK5 inhibitor: BAY-885
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-5866
Abstract: ERK5 (Extracellular signal regulated kinase 5, also known as MAPK7, Gene ID: 5598) is a key integrator of cellular signal transduction and it has been shown to play a role in various cellular processes such… read more here.
Keywords: bay 885; highly potent; potent selective; inhibitor ... See more keywords
Molecular regulation of ERK5 in development of diabetic retinopathy
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.23392
Abstract: Diabetic retinopathy (DR) is a major complication of diabetes, and causes pathological changes in retina blood vessels, as the most common cause of vision loss. Extracellular-signal-regulated kinase 5 (ERK5) is the newest discovered member in… read more here.
Keywords: molecular regulation; diabetic retinopathy; erk5; erk5 signaling ... See more keywords
ERK5 Is a Major Determinant of Chemical Sarcomagenesis: Implications in Human Pathology
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14143509
Abstract: Simple Summary Sarcoma is a heterogeneous group of tumors poorly studied with few therapeutic opportunities. Interestingly, the role of MAPKs still remains unclear in sarcomatous pathology. Here, we describe for the first time the critical… read more here.
Keywords: chemical sarcomagenesis; role; human pathology; pathology ... See more keywords
ERK5 regulates tobacco smoke‑induced urocystic epithelial‑mesenchymal transition in BALB/c mice.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular medicine reports"
DOI: 10.3892/mmr.2017.6457
Abstract: Tobacco smoke (TS) is an important risk factor of bladder cancer. Epithelial‑mesenchymal transition (EMT) is involved in the initiation and development of cancer. The role of extracellular signal‑regulated kinase (ERK) 5 in regulating TS‑induced EMT… read more here.
Keywords: mesenchymal transition; erk5; epithelial mesenchymal; tobacco smoke ... See more keywords