Targeting the functional interplay between endoplasmic reticulum oxidoreductin-1α and protein disulfide isomerase suppresses the progression of cervical cancer
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DOI: 10.1016/j.ebiom.2019.02.041
Abstract: Background Endoplasmic reticulum (ER) oxidoreductin-1α (Ero1α) and protein disulfide isomerase (PDI) constitute the pivotal pathway of oxidative protein folding, and are highly expressed in many cancers. However, whether targeting the functional interplay between Ero1α and… read more here.
Keywords: protein; ero1; endoplasmic reticulum; cervical cancer ... See more keywords
Cancer-associated oxidoreductase ERO1-α promotes immune escape through up-regulation of PD-L1 in human breast cancer
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DOI: 10.18632/oncotarget.14960
Abstract: Many human cancers have been reported to have enhanced expression of the immune checkpoint molecule programmed death-ligand 1 (PD-L1), which binds to programmed cell death-1 (PD-1) expressed on immune cells. PD-L1/PD-1 plays a role in… read more here.
Keywords: ero1; breast cancer; immune escape; expression ... See more keywords
Molecular analysis of human Ero1 reveals novel regulatory mechanisms for oxidative protein folding
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DOI: 10.26508/lsa.201800090
Abstract: This study reveals novel regulatory mechanisms for human Ero1α and Ero1β, including cooperativity for oxygen binding and complex formation with PDI via a novel mixed disulfide linkage. Oxidative protein folding in the ER is driven… read more here.
Keywords: protein; ero1; reveals novel; human ero1 ... See more keywords