Abstract 6148: Disulfide isomerases AGR2, ERp44, and PDIA1 maintain death receptor 5 in an auto-inhibited, monomeric form
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DOI: 10.1158/1538-7445.am2023-6148
Abstract: Previous studies indicated that compounds termed Disulfide bond Disrupting Agents (DDAs) exhibit anti-cancer activity that is associated with downregulation of EGFR/HER1, HER2, and HER3, and activation of Death Receptors 4 and 5 (DR4/5). DDA-induced HER1-3… read more here.
Keywords: agr2 erp44; erp44 pdia1; auto; disulfide isomerases ... See more keywords