In oxygen-deprived tumor cells ERp57 provides radioprotection and ensures proliferation via c-Myc, PLK1 and the AKT pathway
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-86658-5
Abstract: The disulfide isomerase ERp57, originally found in the endoplasmic reticulum, is located in multiple cellular compartments, participates in diverse cell functions and interacts with a huge network of binding partners. It was recently suggested as… read more here.
Keywords: myc plk1; proliferation; erp57; cell ... See more keywords
ERp57 chaperon protein protects neuronal cells from Aβ‐induced toxicity
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15655
Abstract: Alzheimer's disease (AD) is a neurodegenerative disorder whose main pathological hallmark is the accumulation of Amyloid‐β peptide (Aβ) in the form of senile plaques. Aβ can cause neurodegeneration and disrupt cognitive functions by several mechanisms,… read more here.
Keywords: erp57 chaperon; erp57; toxicity; chaperon protein ... See more keywords
Disulfide isomerase ERp57 improves the stability and immunogenicity of H3N2 influenza virus hemagglutinin
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DOI: 10.1186/s12985-020-01325-x
Abstract: Background Hemagglutinin (HA), as the surface immunogenic protein, is the most important component of influenza viruses. Previous studies showed that the stability of HA was significant for HA’s immunogenicity, and many efforts have been made… read more here.
Keywords: immunogenicity; 293 cells; disulfide; immunogenicity h3n2 ... See more keywords
Protein disulfide isomerase ERp57 protects early muscle denervation in experimental ALS
Sign Up to like & getrecommendations! Published in 2021 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-020-01116-z
Abstract: Amyotrophic lateral sclerosis (ALS) is a progressive fatal neurodegenerative disease that affects motoneurons. Mutations in superoxide dismutase 1 (SOD1) have been described as a causative genetic factor for ALS. Mice overexpressing ALS-linked mutant SOD1 develop… read more here.
Keywords: sod1; disulfide isomerase; protein disulfide; mutant sod1 ... See more keywords
Distinct role of ERp57 and ERdj5 as a disulfide isomerase and reductase during ER protein folding
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cell Science"
DOI: 10.1242/jcs.260656
Abstract: ABSTRACT Proteins entering the secretory pathway need to attain native disulfide pairings to fold correctly. For proteins with complex disulfides, this process requires the reduction and isomerisation of non-native disulfides. Two key members of the… read more here.
Keywords: erp57 erdj5; role; erp57; disulfide isomerase ... See more keywords
Role and mechanism of chaperones calreticulin and ERP57 in restoring trafficking to mutant HERG-A561V protein
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2021.4992
Abstract: Long QT syndrome type 2 is caused by a mutation in the human-ether-a-go-go-related gene (HERG) gene encoding the rapidly activating delayed rectifier K-current. HERG is a key cell membrane glycoprotein; however, whether the maturation process… read more here.
Keywords: protein; erp57; a561v; crt ... See more keywords
Insights into the role of ERp57 in cancer
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DOI: 10.7150/jca.48707
Abstract: Endoplasmic reticulum resident protein 57 (ERp57) has a molecular weight of 57 kDa, belongs to the protein disulfide-isomerase (PDI) family, and is primarily located in the endoplasmic reticulum (ER). ERp57 functions in the quality control… read more here.
Keywords: cancer insights; erp57 cancer; role erp57; erp57 ... See more keywords