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   Articles with "err" as a keyword



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ERRα Knockout Promotes M2 Microglial Polarization and Inhibits Ferroptosis in Sepsis-Associated Brain Dysfunction

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recommendations! Published in 2025 at "Molecular Neurobiology"

DOI: 10.1007/s12035-025-05005-1

Abstract: Sepsis-associated brain dysfunction (SABD) is a critical neurological complication with high mortality, yet its pathogenesis remains poorly understood. This study investigated the role of estrogen-related receptor α (ERRα) in SABD pathogenesis using ERRα knockout (KO)… read more here.

Keywords: associated brain; microglial polarization; brain dysfunction; err knockout ... See more keywords

Risk factors for root resorption of second molars associated with impacted mandibular third molars.

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recommendations! Published in 2019 at "International journal of oral and maxillofacial surgery"

DOI: 10.1016/j.ijom.2018.11.005

Abstract: External root resorption (ERR) affecting mandibular second molars (M2) may occur when the adjacent third molar (M3) is impacted in close proximity. This retrospective cohort study aimed to assess the presence, severity, and location of… read more here.

Keywords: second molars; err; risk factors; factors root ... See more keywords

Potential role of microRNA-424 in regulating ERRγ to suppress trophoblast proliferation and invasion in fetal growth restriction.

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recommendations! Published in 2019 at "Placenta"

DOI: 10.1016/j.placenta.2019.07.001

Abstract: BACKGROUND Abnormal expression of estrogen-related receptor γ (ERRγ) protein is associated with fetal growth restriction (FGR). The upstream regulators of ERRγ are still unknown. OBJECTIVE To evaluate the placental expression level of microRNA-424 (miR-424) and… read more here.

Keywords: expression; err; mir 424; invasion ... See more keywords

ERRα-Predictor: A Framework of Ensemble Models for Prediction of ERRα Binders, Antagonists, and Agonists Using Artificial Intelligence

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recommendations! Published in 2025 at "Journal of chemical information and modeling"

DOI: 10.1021/acs.jcim.5c01106

Abstract: Estrogen-related receptor α (ERRα) is considered a promising target for the treatment of cancer and metabolic diseases. The development of comprehensive predictive models for ERRα binders, antagonists, and agonists is of significant importance. In this… read more here.

Keywords: binders antagonists; predictor; antagonists agonists; prediction ... See more keywords

ERRα promotes breast cancer cell dissemination to bone by increasing RANK expression in primary breast tumors

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recommendations! Published in 2018 at "Oncogene"

DOI: 10.1038/s41388-018-0579-3

Abstract: Bone is the most common metastatic site for breast cancer. Estrogen-related-receptor alpha (ERRα) has been implicated in cancer cell invasiveness. Here, we established that ERRα promotes spontaneous metastatic dissemination of breast cancer cells from primary… read more here.

Keywords: breast cancer; bone; err; expression ... See more keywords

The nuclear receptor ERR cooperates with the cardiogenic factor GATA4 to orchestrate cardiomyocyte maturation.

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recommendations! Published in 2022 at "Nature communications"

DOI: 10.1038/s41467-022-29733-3

Abstract: Estrogen-related receptors (ERR) α and γ were shown recently to serve as regulators of cardiac maturation, yet the underlying mechanisms have not been delineated. Herein, we find that ERR signaling is necessary for induction of… read more here.

Keywords: gata4; factor gata4; maturation; err ... See more keywords

Experimental and computational investigation on the formation pathway of [RuCl2(CO)2(ERR')2] (E = S, Se, Te; R, R' = Me, Ph) from [RuCl2(CO)3]2 and ERR'.

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recommendations! Published in 2022 at "Dalton transactions"

DOI: 10.1039/d2dt02018a

Abstract: The pathways to the formation of the series of [RuCl2(CO)2(ERR')2] (E = S, Se, Te; R, R' = Me, Ph) complexes from [RuCl2(CO)3]2 and ERR' have been explored experimentally in THF and CH2Cl2, and computationally… read more here.

Keywords: thf; reaction; rucl2 err; formation ... See more keywords

ERRα activates SHMT2 transcription to enhance the resistance of breast cancer to lapatinib via modulating the mitochondrial metabolic adaption

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recommendations! Published in 2020 at "Bioscience Reports"

DOI: 10.1042/bsr20192465

Abstract: Abstract Lapatinib, a tyrosine kinase inhibitor, can initially benefit the patients with breast tumors but fails in later treatment due to the inevitable development of drug resistance. Estrogen-related receptor α (ERRα) modulates the metabolic adaptations… read more here.

Keywords: err; cancer; transcription; resistance ... See more keywords

Loss of Estrogen-Related Receptor Alpha Facilitates Angiogenesis in Endothelial Cells

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recommendations! Published in 2019 at "Molecular and Cellular Biology"

DOI: 10.1128/mcb.00411-18

Abstract: Estrogen-related receptors (ERRs) have emerged as major metabolic regulators in various tissues. However, their expression and function in the vasculature remains unknown. ABSTRACT Estrogen-related receptors (ERRs) have emerged as major metabolic regulators in various tissues.… read more here.

Keywords: err; estrogen; estrogen related; loss estrogen ... See more keywords

ERRγ, a Novel Biomarker, Associates with Pathoglycemia of Endometrial Cancer to Predict Myometrial Invasion

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recommendations! Published in 2022 at "Journal of Oncology"

DOI: 10.1155/2022/5283388

Abstract: We aim to investigate the correlation between the expression of estrogen-related receptor γ (ERRγ) and endometrial cancer (EC) progression and to evaluate the potential of ERRγ as a new biomarker for EC diagnosis. We analyzed… read more here.

Keywords: endometrial cancer; myometrial invasion; biomarker; invasion ... See more keywords

PGC1α suppresses prostate cancer cell invasion through ERRα transcriptional control.

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recommendations! Published in 2019 at "Cancer research"

DOI: 10.1158/0008-5472.can-19-1231

Abstract: The peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC1α) is a prostate tumor suppressor that controls the balance between anabolism and catabolism. PGC1A downregulation in prostate cancer is causally associated with the development of metastasis.… read more here.

Keywords: pgc1; prostate cancer; err; cancer cell ... See more keywords