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Cholesterol promotes EGFR-TKIs resistance in NSCLC by inducing EGFR/Src/Erk/SP1 signaling-mediated ERRα re-expression

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3 Published in 2022 at "Molecular Cancer"

DOI: 10.1186/s12943-022-01547-3

Abstract: Background The use of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) brings remarkable benefits for the survival of patients with advanced NSCLC harboring EGFR mutations. Unfortunately, acquired resistance seems to be inevitable and limits… read more here.

Keywords: resistance; cholesterol; err expression; egfr tkis ... See more keywords