The 1-β-methyl group confers a lower affinity of l,d-transpeptidase LdtMt2 for ertapenem than for imipenem.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.01.082
Abstract: L,D-transpeptidases, widely distributed in bacteria and even in the difficult-to-treat ESKAPE pathogens, can confer antibacterial resistance against the traditional β-lactam antibiotics through bypass of the 4 → 3 transpeptide linkage. LdtMt2, a l,d-transpeptidase in Mycobacteria tuberculosis, is… read more here.
Keywords: transpeptidase; ertapenem; affinity; methyl group ... See more keywords
Single-Dose Antibiotic Prophylaxis with Ertapenem Increases Compliance With Recommendations for Surgical Antibiotic Prophylaxis in Elective Colorectal Surgery: A Retrospective, Single-Center Analysis.
Sign Up to like & getrecommendations! Published in 2023 at "Surgical infections"
DOI: 10.1089/sur.2022.253
Abstract: Background: Compliance with guideline recommendations for surgical antibiotic prophylaxis (SAP) in colorectal surgery, particularly redosing, has been suboptimal at many institutions including ours. This study aimed to evaluate if single-dose antibiotic prophylaxis with ertapenem improves… read more here.
Keywords: compliance; antibiotic prophylaxis; surgery; dose antibiotic ... See more keywords
2447. Ertapenem and Faropenem for the Treatment of Drug-Resistant Tuberculosis
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DOI: 10.1093/ofid/ofy210.2100
Abstract: Abstract Background Carbapenems are a class of β-lactam antibiotics which include imipenem, meropenem and ertapenem. More recently, a new oral carbapenem (faropenem) have been marketed in a limited number of countries (in particular, India and… read more here.
Keywords: drug resistant; ertapenem faropenem; treatment; ertapenem ... See more keywords
Perioperative prophylaxis with ertapenem reduced infections caused by extended-spectrum betalactamase-producting Enterobacteriaceae after kidney transplantation
Sign Up to like & getrecommendations! Published in 2019 at "BMC Nephrology"
DOI: 10.1186/s12882-019-1461-4
Abstract: BackgoundIn recent years we have witnessed an increase in infections due to multidrug-resistant organisms in kidney transplant recipients (KTR). In our setting, we have observed a dramatic increase in infections caused by extended-spectrum betalactamase-producing (ESBL)… read more here.
Keywords: ertapenem; caused extended; infections caused; prophylaxis ... See more keywords
The Radiation Sterilization of Ertapenem Sodium in the Solid State
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DOI: 10.3390/molecules24162944
Abstract: For the first time, the influence of ionising radiation on the physicochemical properties of ertapenem in solid state was studied. During our studies, we evaluated the possibility of applying radiosterilization to obtain sterile ertapenem. Spectroscopic… read more here.
Keywords: solid state; sterilization ertapenem; ertapenem; radiation sterilization ... See more keywords