Studies towards the synthesis of ertugliflozin from l-Arabinose
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DOI: 10.1016/j.tet.2018.08.005
Abstract: Abstract A new method for the diastereoselective synthesis of enantiomerically pure ertugliflozin was developed. The crucial step involves an aldol condensation between 1-(4-chloro-3-(4-ethoxybenzyl)phenyl)ethanone and (4R,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-2,2-dimethyl-5-((trityloxy)methyl)-1,3-dioxolane-4-carbaldehyde, which was prepared from known 2-C-trityloxymethyl-2,3-O-isopropylidene- l -erythrose (easily accessible… read more here.
Keywords: ertugliflozin arabinose; towards synthesis; studies towards; ertugliflozin ... See more keywords