Concise Review: Bipotent Megakaryocytic‐Erythroid Progenitors: Concepts and Controversies
Sign Up to like & getrecommendations! Published in 2018 at "STEM CELLS"
DOI: 10.1002/stem.2834
Abstract: Hematopoietic stem and progenitor cells maintain blood formation throughout our lifetime by undergoing long‐ and short‐term self‐renewal, respectively. As progenitor cells progress through the hematopoiesis process, their differentiation capabilities narrow, such that the precursors become… read more here.
Keywords: erythroid; bipotent megakaryocytic; erythroid progenitors; megakaryocytic erythroid ... See more keywords
KLF1 mutation E325K induces cell cycle arrest in erythroid cells differentiated from congenital dyserythropoietic anemia patient-specific induced pluripotent stem cells.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental hematology"
DOI: 10.1016/j.exphem.2019.03.001
Abstract: Krüppel-like factor 1 (KLF1), a transcription factor controlling definitive erythropoiesis, is involved in sequential control of terminal cell division and enucleation via fine regulation of key cell cycle regulator gene expression in erythroid lineage cells.… read more here.
Keywords: erythroid; cda; cell cycle; erythroid cells ... See more keywords
Knockdown of spliceosome U2AF1 significantly inhibits the development of human erythroid cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14370
Abstract: U2AF1 (U2AF35) is the small subunit of the U2 auxiliary factor (U2AF) that constitutes the U2 snRNP (small nuclear ribonucleoproteins) of the spliceosome. Here, we examined the function of U2AF1 in human erythropoiesis. First, we… read more here.
Keywords: erythroid; human erythropoiesis; signalling pathway; u2af1 significantly ... See more keywords
Stimulation of the Proliferation of Mouse and Human Definitive Erythroid Progenitors By Activation of the Vitamin D Receptor Transcription Factor
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-113846
Abstract: How the proliferation of erythroid progenitors is regulated is still now well understood. We found, using a computational analysis, that the vitamin D receptor(Vdr) nuclear hormone receptor transcription factor gene is expressed in the fetal… read more here.
Keywords: erythroid; transcription factor; erythroid progenitors; receptor ... See more keywords
p53 activation during ribosome biogenesis regulates normal erythroid differentiation.
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood.2019003439
Abstract: The role of ribosome biogenesis in erythroid development is supported by the recognition of erythroid defects in ribosomopathies in both Diamond-Blackfan anemia and 5q- syndrome. Whether ribosome biogenesis exerts a regulatory function on normal erythroid… read more here.
Keywords: p53 activation; erythroid; biogenesis; ribosome biogenesis ... See more keywords
Ribosome profiling uncovers selective mRNA translation associated with eIF2 phosphorylation in erythroid progenitors
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0193790
Abstract: The regulation of translation initiation factor 2 (eIF2) is important for erythroid survival and differentiation. Lack of iron, a critical component of heme and hemoglobin, activates Heme Regulated Inhibitor (HRI). This results in phosphorylation of… read more here.
Keywords: erythroid; ribosome profiling; mrna translation; translation ... See more keywords
Cognitive enhancing and antioxidant effects of tetrahydroxystilbene glucoside in Aβ1-42-induced neurodegeneration in mice.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of integrative neuroscience"
DOI: 10.31083/jin-170059
Abstract: Polyhydroxy stilbenes have been reported to possess various biological activities and have potential for treatment of Alzheimer's disease. Tetrahydroxystilbene glucoside is one of the major polyhydroxy stilbenes, which provides the underlying therapeutic activities for neuroprotective… read more here.
Keywords: erythroid; alzheimer disease; kelch like; tetrahydroxystilbene glucoside ... See more keywords
Loss of Forkhead box M1 promotes erythropoiesis through increased proliferation of erythroid progenitors
Sign Up to like & getrecommendations! Published in 2017 at "Haematologica"
DOI: 10.3324/haematol.2016.156257
Abstract: Forkhead box M1 (FOXM1) belongs to the forkhead/winged-helix family of transcription factors and regulates a network of proliferation-associated genes. Its abnormal upregulation has been shown to be a key driver of cancer progression and an… read more here.
Keywords: erythroid; foxm1; forkhead box; proliferation erythroid ... See more keywords