Concise Review: Bipotent Megakaryocytic‐Erythroid Progenitors: Concepts and Controversies
Sign Up to like & getrecommendations! Published in 2018 at "STEM CELLS"
DOI: 10.1002/stem.2834
Abstract: Hematopoietic stem and progenitor cells maintain blood formation throughout our lifetime by undergoing long‐ and short‐term self‐renewal, respectively. As progenitor cells progress through the hematopoiesis process, their differentiation capabilities narrow, such that the precursors become… read more here.
Keywords: erythroid; bipotent megakaryocytic; erythroid progenitors; megakaryocytic erythroid ... See more keywords
Identification and Analysis of Mouse Erythroid Progenitor Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9631-5_11
Abstract: The most common cell type in the human body, the red blood cell or erythrocyte, has a life span of approximately 3 months. To compensate for this massive cellular requirement and short life span, the major… read more here.
Keywords: erythroid progenitors; progenitor cells; identification analysis; erythroid progenitor ... See more keywords
The Molecular Signature of Megakaryocyte-Erythroid Progenitors Reveals a Role for the Cell Cycle in Fate Specification
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.10.084
Abstract: SUMMARY Megakaryocytic-erythroid progenitors (MEPs) give rise to the cells that produce red blood cells and platelets. Although the mechanisms underlying megakaryocytic (MK) and erythroid (E) maturation have been described, those controlling their specification from MEPs… read more here.
Keywords: erythroid progenitors; cell; specification; cell cycle ... See more keywords
Enhanced Renewal of Erythroid Progenitors in Myelodysplastic Anemia by Peripheral Serotonin.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.02.071
Abstract: Tryptophan as the precursor of several active compounds, including kynurenine and serotonin, is critical for numerous important metabolic functions. Enhanced tryptophan metabolism toward the kynurenine pathway has been associated with myelodysplastic syndromes (MDSs), which are… read more here.
Keywords: enhanced renewal; erythroid progenitors; myelodysplastic anemia; serotonin ... See more keywords
3121 – ERYTHROPOIETIN DEPENDENT SIGNALING IN ERYTHROBLASTIC ISLAND MACROPHAGES INDUCES PGE2 DEPENDENT DIFFERENTIATION OF STRESS ERYTHROID PROGENITORS
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2020.09.130
Abstract: Inflammation caused by infection or tissue damage has a profound effect on hematopoiesis. Pro-inflammatory cytokines skew hematopoiesis to increase the production of myeloid effector cells, but this change comes with a cost as erythropoiesis is… read more here.
Keywords: differentiation; erythropoiesis; stress; erythroid progenitors ... See more keywords
High erythroferrone expression in CD71+ erythroid progenitors predicts superior survival in myelodysplastic syndromes
Sign Up to like & getrecommendations! Published in 2021 at "British Journal of Haematology"
DOI: 10.1111/bjh.17314
Abstract: Ineffective erythropoiesis and iron overload are common in myelodysplastic syndromes (MDS). Erythroferrone (ERFE) and growth/differentiation factor 15 (GDF15) are two regulators of iron homeostasis produced by erythroid progenitors. Elevated systemic levels of ERFE and GDF15… read more here.
Keywords: myelodysplastic syndromes; erythroid progenitors; erfe gdf15; expression ... See more keywords
The N-Terminal 5-68 Amino Acids Domain of the Minor Capsid Protein VP1 of Human Parvovirus B19 Enters Human Erythroid Progenitors and Inhibits B19 Infection
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Virology"
DOI: 10.1128/jvi.00466-21
Abstract: Human parvovirus B19 infection causes severe hematological disorders, including transient aplastic crisis, pure red cell aplasia, and hydrops fetalis. A productive B19 infection is highly restricted to human erythroid progenitors in human bone marrow and… read more here.
Keywords: human erythroid; infection; erythroid progenitors; b19 infection ... See more keywords
Stimulation of the Proliferation of Mouse and Human Definitive Erythroid Progenitors By Activation of the Vitamin D Receptor Transcription Factor
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-113846
Abstract: How the proliferation of erythroid progenitors is regulated is still now well understood. We found, using a computational analysis, that the vitamin D receptor(Vdr) nuclear hormone receptor transcription factor gene is expressed in the fetal… read more here.
Keywords: erythroid; transcription factor; erythroid progenitors; receptor ... See more keywords
Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche.
Sign Up to like & getrecommendations! Published in 2019 at "Blood advances"
DOI: 10.1182/bloodadvances.2019000375
Abstract: Anemic stress induces the proliferation of stress erythroid progenitors in the murine spleen that subsequently differentiate to generate erythrocytes to maintain homeostasis. This process relies on the interaction between stress erythroid progenitors and the signals… read more here.
Keywords: erythroid progenitors; stress erythroid; proliferation; stress ... See more keywords