Myotonic dystrophy kinase‐related CDC42‐binding kinase α, a new transferrin receptor type 2‐binding partner, is a regulator of erythropoiesis
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Hematology"
DOI: 10.1002/ajh.26104
Abstract: Efficient erythropoiesis relies on the expression of the transferrin receptor type 2 (TFR2). In erythroid precursors, TFR2 facilitates the export of the erythropoietin receptor (EPOR) to cell surface, which ensures the survival and proliferation of… read more here.
Keywords: kinase; transferrin receptor; receptor type; myotonic dystrophy ... See more keywords
Erythropoiesis and chronic kidney disease–related anemia: From physiology to new therapeutic advancements
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DOI: 10.1002/med.21527
Abstract: Erythropoiesis is triggered by hypoxia and is strictly regulated by hormones, growth factors, cytokines, and vitamins to ensure an adequate oxygen delivery to all body cells. Abnormalities in one or more of these factors may… read more here.
Keywords: chronic kidney; physiology; new therapeutic; erythropoiesis ... See more keywords
Pleiotropic effect of erythropoiesis-stimulating agents on circulating endothelial progenitor cells in dialysis patients
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Experimental Nephrology"
DOI: 10.1007/s10157-021-02071-2
Abstract: Recent studies have suggested that erythropoiesis-stimulating agents (ESAs) may accelerate not only angiogenesis but also vasculogenesis, beyond erythropoiesis. We conducted a 12-week prospective study in 51 dialysis patients; 13 were treated with recombinant human erythropoietin… read more here.
Keywords: erythropoiesis stimulating; stimulating agents; endothelial progenitor; dialysis patients ... See more keywords
Genome-wide analysis of pseudogenes reveals HBBP1's human-specific essentiality in erythropoiesis and implication in β-thalassemia.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental cell"
DOI: 10.1016/j.devcel.2020.12.019
Abstract: The human genome harbors 14,000 duplicated or retroposed pseudogenes. Given their functionality as regulatory RNAs and low conservation, we hypothesized that pseudogenes could shape human-specific phenotypes. To test this, we performed co-expression analyses and found… read more here.
Keywords: genome wide; thalassemia; wide analysis; analysis pseudogenes ... See more keywords
ERYTHROPOIESIS SUPPRESSION BY BACTERIAL LIPOSACCHARIDES IS EXTRINSICALLY MEDIATED INDEPENDENTLY OF G-CSF
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2019.06.331
Abstract: The central macrophage (MΦ) in erythroblastic islands (EI) is critical to erythropoiesis by providing iron and growth factors, and mediating enucleation of the maturing erythroblasts. As MΦ are key effectors of inflammation, we investigated the… read more here.
Keywords: mice; gcsfr mice; erythropoiesis; erythropoiesis suppression ... See more keywords
ITERATIVE AND PLEIOTROPIC ROLES OF ENDOTHELIAL CELLS IN HUMAN HEMATOPOIETIC ERYTHROPOIESIS
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2019.06.442
Abstract: Local tissue microenvironments regulate directly the hematopoietic development and cell fate specification of both stem cells and lineage-committed progenitor cells. The identification of hematopoietic niches and the mechanisms by which they regulate cell fate specification… read more here.
Keywords: erythropoiesis; human hematopoietic; iterative pleiotropic; endothelial cells ... See more keywords
Nrf2 deficiency in mice attenuates erythropoietic stress-related macrophage hypercellularity.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental hematology"
DOI: 10.1016/j.exphem.2020.02.005
Abstract: Erythropoiesis in the bone marrow and spleen depends upon intricate interactions between the resident macrophages and erythroblasts. Our study focuses on identifying the role of the Nuclear Factor Erythroid 2-related factor 2 (Nrf2) during recovery… read more here.
Keywords: stress erythropoiesis; stress; erythropoiesis; macrophage hypercellularity ... See more keywords
3043 – A PIPELINE TO IMAGE HEMATOPOIETIC DIFFERENTIATION REVEALS THE ARCHITECTURE OF ERYTHROPOIESIS IN THE BONE MARROW
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DOI: 10.1016/j.exphem.2020.09.063
Abstract: The anatomy of differentiation in the BM is poorly understood due to a lack of markers to image stepwise HSPC differentiation. We immunophenotyped all types of multipotent and lineage committed HSPC and identified 56 cell… read more here.
Keywords: pre; differentiation; pipeline; erythropoiesis ... See more keywords
3121 – ERYTHROPOIETIN DEPENDENT SIGNALING IN ERYTHROBLASTIC ISLAND MACROPHAGES INDUCES PGE2 DEPENDENT DIFFERENTIATION OF STRESS ERYTHROID PROGENITORS
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2020.09.130
Abstract: Inflammation caused by infection or tissue damage has a profound effect on hematopoiesis. Pro-inflammatory cytokines skew hematopoiesis to increase the production of myeloid effector cells, but this change comes with a cost as erythropoiesis is… read more here.
Keywords: differentiation; erythropoiesis; stress; erythroid progenitors ... See more keywords
The intricate role of selenium and selenoproteins in erythropoiesis
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.578
Abstract: ABSTRACT Selenium (Se) is incorporated as the 21st amino acid selenocysteine (Sec) into the growing polypeptide chain of proteins involved in redox gatekeeper functions. Erythropoiesis presents a particular problem to redox regulation as the presence… read more here.
Keywords: intricate role; stress; role; selenium ... See more keywords
Defining the functionally sufficient regulatory region and liver-specific roles of the erythropoietin gene by transgene complementation.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119075
Abstract: BACKGROUND Erythropoietin (EPO) is an essential growth factor for erythroid cells and is mainly secreted from the kidneys and subsidiarily from the livers of adult mammals in an anemia/hypoxia-inducible manner. AIM AND METHOD To elucidate… read more here.
Keywords: liver specific; epo gene; transgene complementation; gene ... See more keywords