Absolute Bioavailability of Esaxerenone and Food Effects on its Pharmacokinetics After a Single Oral Dose in Healthy Japanese Subjects: An Open-Label Crossover Study
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DOI: 10.1007/s12325-019-00956-z
Abstract: IntroductionTo investigate the absolute bioavailability of esaxerenone and the effects of food on its pharmacokinetics (PK) after a single oral dose in healthy Japanese subjects.MethodsTwenty-four Japanese males aged 20–45 years were randomised to six groups (each… read more here.
Keywords: esaxerenone; oral dose; absolute bioavailability; single oral ... See more keywords
Effect of a novel nonsteroidal selective mineralocorticoid receptor antagonist, esaxerenone (CS-3150), on blood pressure and renal injury in high salt-treated type 2 diabetic mice
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DOI: 10.1038/s41440-019-0211-0
Abstract: Although beneficial antihypertensive and antialbuminuric effects of steroidal mineralocorticoid receptor (MR) antagonists have been shown, the use of these drugs has been clinically limited in diabetic kidney disease (DKD) because of the high incidence of… read more here.
Keywords: esaxerenone; diabetic mice; injury; blood pressure ... See more keywords
Antihypertensive effects and safety of esaxerenone in patients with moderate kidney dysfunction
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DOI: 10.1038/s41440-020-00585-y
Abstract: Renin–angiotensin system inhibitors are recommended for treating hypertension with chronic kidney disease. The addition of a mineralocorticoid receptor blocker may be one option to achieve target blood pressure. We investigated the efficacy and safety of… read more here.
Keywords: esaxerenone; kidney dysfunction; patients moderate; therapy ... See more keywords
Pharmacokinetic interactions of esaxerenone with amlodipine and digoxin in healthy Japanese subjects
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DOI: 10.1186/s40360-020-00423-4
Abstract: Background To investigate the effects of coadministration of esaxerenone with amlodipine on the pharmacokinetics (PK) of each drug, and of esaxerenone on the PK of digoxin. Methods In three open-label, single-sequence, crossover studies, healthy Japanese… read more here.
Keywords: digoxin; esaxerenone; day days; healthy japanese ... See more keywords
Association of Antihypertensive Effects of Esaxerenone with the Internal Sodium Balance in Dahl Salt-Sensitive Hypertensive Rats
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DOI: 10.3390/ijms23168915
Abstract: Background: The nonsteroidal mineralocorticoid receptor blocker esaxerenone is effective in reducing blood pressure (BP). Objective: In this study, we investigated esaxerenone-driven sodium homeostasis and its association with changes in BP in Dahl salt-sensitive (DSS) hypertensive… read more here.
Keywords: sodium; salt sensitive; dahl salt; treated rats ... See more keywords