Human ESC-Derived Cardiomyocytes Restore Function in Infarcted Hearts of Non-Human Primates
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DOI: 10.1038/nbt.4162
Abstract: Pluripotent stem cell–derived cardiomyocyte grafts can remuscularize substantial amounts of infarcted myocardium and beat in synchrony with the heart, but in some settings cause ventricular arrhythmias. It is unknown whether human cardiomyocytes can restore cardiac… read more here.
Keywords: restore function; derived cardiomyocytes; cardiomyocytes restore; esc derived ... See more keywords
245-OR: CIS-Regulatory Architecture of Human ESC-Derived Hypothalamic Neuron Differentiation Aids in Variant-to-Gene Mapping of Type 2 Diabetes Related Traits
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DOI: 10.2337/db20-245-or
Abstract: Dysregulation of hypothalamus-mediated metabolic homeostasis influences risk factors for T2D, such as BMI, pubertal timing and sleep. However, the gene regulatory landscape of the hypothalamus remains unclear. We characterized the physical relationships among gene promoters… read more here.
Keywords: differentiation; cis regulatory; esc derived; derived hypothalamic ... See more keywords