Charting the Path to Systemic Therapy De-escalation-Oligometastatic Kidney Cancer as a Paradigm.
Sign Up to like & getrecommendations! Published in 2024 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2023.7266
Abstract: This Viewpoint discusses whether select patient populations may benefit from de-escalation rather than escalation of systemic therapy for kidney cancer. read more here.
Keywords: escalation; systemic therapy; kidney cancer;
Initiation of and Escalation to High-Intensity Drinking in Young Adults.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA pediatrics"
DOI: 10.1001/jamapediatrics.2022.5642
Abstract: Importance High-intensity drinking (HID) (≥10 drinks in a row) is associated with acute negative outcomes. Identifying factors associated with HID initiation in adolescence and how it is associated with young adulthood outcomes can inform screening… read more here.
Keywords: hid; escalation; age years; alcohol ... See more keywords
Treatment‐Free Remission in Chronic Phase Chronic Myeloid Leukemia After Nilotinib De‐Escalation: 96‐Week Update of the DANTE Study
Sign Up to like & getrecommendations! Published in 2025 at "Hematological Oncology"
DOI: 10.1002/hon.70126
Abstract: Treatment‐free remission (TFR) in chronic myeloid leukemia (CML) can be considered for patients in sustained deep molecular response (DMR) who can discontinue tyrosine kinase inhibitors (TKIs) while maintaining responses. Studies suggest that TKI de‐escalation before… read more here.
Keywords: week; treatment free; escalation; sustained dmr ... See more keywords
Defusing disruption: A rapid qualitative analysis examining hospitalist experiences navigating behavioral escalation events.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of hospital medicine"
DOI: 10.1002/jhm.70121
Abstract: BACKGROUND Behavioral escalation events have become commonplace in the acute care setting. Disruptive patient behaviors contribute to workplace injuries and can compromise patient care and safety. Despite frequently encountering behavioral escalation, limited research exists on… read more here.
Keywords: behavioral escalation; escalation events; escalation; medicine ... See more keywords
Toxicity‐dependent feasibility bounds for the escalation with overdose control approach in phase I cancer trials
Sign Up to like & getrecommendations! Published in 2017 at "Statistics in Medicine"
DOI: 10.1002/sim.7280
Abstract: Phase I trials of anti‐cancer therapies aim to identify a maximum tolerated dose (MTD), defined as the dose that causes unacceptable toxicity in a target proportion of patients. Both rule‐based and model‐based methods have been… read more here.
Keywords: dependent feasibility; feasibility; approach; escalation ... See more keywords
MS treatment de-escalation: review and commentary
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Neurology"
DOI: 10.1007/s00415-024-12584-x
Abstract: Almost all currently licensed disease-modifying therapies (DMTs) for MS treatment require prolonged if not lifelong administration. Yet, as people age, the immune system has increasingly reduced responsiveness, known as immunosenescence. Many MS DMTs reduce the… read more here.
Keywords: age; treatment; escalation review; treatment escalation ... See more keywords
Mitigation of privilege escalation attack using kernel data relocation mechanism
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Information Security"
DOI: 10.1007/s10207-024-00890-4
Abstract: Kernel memory corruption, which leads to a privilege escalation attack, has been reported as a security threat to operating systems. To mitigate privilege escalation attacks, several security mechanisms are proposed. Kernel address space layout randomization… read more here.
Keywords: escalation; privilege escalation; privileged information; relocation ... See more keywords
Refining risk stratification in HR-positive/HER2-negative early breast cancer: how to select patients for treatment escalation?
Sign Up to like & getrecommendations! Published in 2022 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-022-06535-1
Abstract: Despite advances in adjuvant therapeutic strategies, many patients with hormone receptor (HR)-positive/HER2-negative early breast cancer (EBC) experience disease recurrence, even many years after primary surgery. The aim of this review is: (i) to point out… read more here.
Keywords: risk; treatment; risk stratification; positive her2 ... See more keywords
Guided de-escalation of DAPT in acute coronary syndrome patients undergoing percutaneous coronary intervention with BVS implantation: a post-hoc analysis from the randomized TROPICAL-ACS trial
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-019-01811-2
Abstract: To investigate the safety and efficacy of an early platelet function testing (PFT)-guided de-escalation of dual antiplatelet treatment (DAPT) in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI) with bioresorbable vascular scaffolds (BVS).… read more here.
Keywords: hoc analysis; post hoc; acs; implantation ... See more keywords
Evaluating Racial/Ethnic Differences in Care Escalation Among COVID-19 Patients in a Home-Based Hospital
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Racial and Ethnic Health Disparities"
DOI: 10.1007/s40615-022-01270-1
Abstract: The novel coronavirus disease 2019 (COVID-19) has infected over 414 million people worldwide with 5.8 million deaths, as of February 2022. Telemedicine-based interventions to expand healthcare systems’ capacity and reduce infection risk have rapidly increased… read more here.
Keywords: racial ethnic; care escalation; escalation; home based ... See more keywords
Faster escalation from first drink to first intoxication as a risk factor for binge and high-intensity drinking among adolescents.
Sign Up to like & getrecommendations! Published in 2019 at "Addictive behaviors"
DOI: 10.1016/j.addbeh.2019.01.003
Abstract: INTRODUCTION Age of first drink is a key risk factor for adolescent high-risk alcohol use. The current study examined whether speed of escalation from first drink to first intoxication is an additional risk factor, and… read more here.
Keywords: intoxication; first intoxication; first drink; high intensity ... See more keywords