Initiation of and Escalation to High-Intensity Drinking in Young Adults.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA pediatrics"
DOI: 10.1001/jamapediatrics.2022.5642
Abstract: Importance High-intensity drinking (HID) (≥10 drinks in a row) is associated with acute negative outcomes. Identifying factors associated with HID initiation in adolescence and how it is associated with young adulthood outcomes can inform screening… read more here.
Keywords: hid; escalation; age years; alcohol ... See more keywords
Toxicity‐dependent feasibility bounds for the escalation with overdose control approach in phase I cancer trials
Sign Up to like & getrecommendations! Published in 2017 at "Statistics in Medicine"
DOI: 10.1002/sim.7280
Abstract: Phase I trials of anti‐cancer therapies aim to identify a maximum tolerated dose (MTD), defined as the dose that causes unacceptable toxicity in a target proportion of patients. Both rule‐based and model‐based methods have been… read more here.
Keywords: dependent feasibility; feasibility; approach; escalation ... See more keywords
Refining risk stratification in HR-positive/HER2-negative early breast cancer: how to select patients for treatment escalation?
Sign Up to like & getrecommendations! Published in 2022 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-022-06535-1
Abstract: Despite advances in adjuvant therapeutic strategies, many patients with hormone receptor (HR)-positive/HER2-negative early breast cancer (EBC) experience disease recurrence, even many years after primary surgery. The aim of this review is: (i) to point out… read more here.
Keywords: risk; treatment; risk stratification; positive her2 ... See more keywords
Guided de-escalation of DAPT in acute coronary syndrome patients undergoing percutaneous coronary intervention with BVS implantation: a post-hoc analysis from the randomized TROPICAL-ACS trial
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-019-01811-2
Abstract: To investigate the safety and efficacy of an early platelet function testing (PFT)-guided de-escalation of dual antiplatelet treatment (DAPT) in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI) with bioresorbable vascular scaffolds (BVS).… read more here.
Keywords: hoc analysis; post hoc; acs; implantation ... See more keywords
Evaluating Racial/Ethnic Differences in Care Escalation Among COVID-19 Patients in a Home-Based Hospital
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Racial and Ethnic Health Disparities"
DOI: 10.1007/s40615-022-01270-1
Abstract: The novel coronavirus disease 2019 (COVID-19) has infected over 414 million people worldwide with 5.8 million deaths, as of February 2022. Telemedicine-based interventions to expand healthcare systems’ capacity and reduce infection risk have rapidly increased… read more here.
Keywords: racial ethnic; care escalation; escalation; home based ... See more keywords
Faster escalation from first drink to first intoxication as a risk factor for binge and high-intensity drinking among adolescents.
Sign Up to like & getrecommendations! Published in 2019 at "Addictive behaviors"
DOI: 10.1016/j.addbeh.2019.01.003
Abstract: INTRODUCTION Age of first drink is a key risk factor for adolescent high-risk alcohol use. The current study examined whether speed of escalation from first drink to first intoxication is an additional risk factor, and… read more here.
Keywords: intoxication; first intoxication; first drink; high intensity ... See more keywords
Trial designs and results supporting treatment de-escalation and escalation.
Sign Up to like & getrecommendations! Published in 2017 at "Breast"
DOI: 10.1016/j.breast.2017.06.020
Abstract: Trials for escalation and de-escalation of treatment aim to improve patient care, but from different sides of the same coin with respect to disease control and burdens of treatment. De-escalation of therapy is inherently a… read more here.
Keywords: trial designs; treatment escalation; treatment; designs results ... See more keywords
De-escalation of treatment in HER2-positive breast cancer: Determinants of response and mechanisms of resistance.
Sign Up to like & getrecommendations! Published in 2017 at "Breast"
DOI: 10.1016/j.breast.2017.06.022
Abstract: Overexpression and/or gene amplification of HER2, a crucial member of the HER family of four receptors, occur in about 15-20% of breast cancers and define an aggressive subtype of the disease. Activated HER homo and… read more here.
Keywords: breast; treatment; resistance; therapy ... See more keywords
Rolling dose escalation with overdose control: An efficient and safe phase 1 design.
Sign Up to like & getrecommendations! Published in 2021 at "Contemporary clinical trials"
DOI: 10.1016/j.cct.2021.106436
Abstract: In phase 1 dose escalation studies, dose limiting toxicities (DLTs) are defined as adverse events of concern occurring during a predefined time window after first dosing of patients. Standard dose escalation designs, such as the… read more here.
Keywords: dose escalation; crm; overdose control; escalation ... See more keywords
Systematic De-escalation of Successful Triple Antiretroviral Therapy to Dual Therapy with Dolutegravir plus Emtricitabine or Lamivudine in Swiss HIV-positive Persons
Sign Up to like & getrecommendations! Published in 2018 at "EClinicalMedicine"
DOI: 10.1016/j.eclinm.2018.11.005
Abstract: Background Studies increasingly suggest that the efficacy of certain dual antiretroviral therapy (ART) combinations is equal to triple ART. Increasing concerns among HIV-positive patients and physicians in Switzerland include ART cost and long-term ART safety… read more here.
Keywords: dolutegravir; art; therapy; escalation ... See more keywords
Escalation of negative social exchange: Reflexive punishment or deliberative deterrence?
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Experimental Social Psychology"
DOI: 10.1016/j.jesp.2019.103823
Abstract: Abstract Negative escalation of social exchange exacts significant costs on both individuals and society. Instead of in-kind reciprocity—an eye for an eye—negative reciprocity may escalate, taking two eyes for an eye. We tested two competing… read more here.
Keywords: social exchange; deterrence; escalation; punishment ... See more keywords