Examining the Evidence for Escalating Antimicrobial Regimens in Febrile Oncology and Hematopoietic Stem Cell Transplant Patients Admitted to the PICU: An Observational Study*
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DOI: 10.1097/pcc.0000000000003238
Abstract: OBJECTIVES: To examine whether escalating antimicrobial treatment in pediatric oncology and hematopoietic cell transplantation (HSCT) patients admitted to the PICU is supported by culture data or affects patient outcomes. DESIGN: Retrospective cross-sectional study. SETTING: Quaternary… read more here.
Keywords: oncology; escalating antimicrobial; escalation; escalation group ... See more keywords
Outcomes Associated with De-escalation of Antibiotics to Target Positive Cultures when Treating Febrile Neutropenia.
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DOI: 10.1177/08971900221132120
Abstract: Background: Patients with hematologic malignancies frequently develop febrile neutropenia (FN) and subsequently receive long courses of broad-spectrum antibiotics. Limited data is available on de-escalation strategies. Methods: This was a retrospective observational cohort study of adult… read more here.
Keywords: conventional group; escalation; escalation group; group ... See more keywords
Response Adapted Dasatinib De-Escalation Strategy Compared to Upfront Low-Dose Dasatinib: A Prospective Cohort Study
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DOI: 10.1182/blood-2024-206740
Abstract: The prognosis of chronic myeloid leukemia (CML) has improved with daily tyrosine kinase inhibitors (TKIs), allowing most patients to expect a normal life expectancy. However, TKI treatment is costly and has side effects (Bower H,… read more here.
Keywords: low dose; cohort; escalation group; group ... See more keywords