Abstract CT097: IMM27M, a humanized Fc-engineered anti CTLA-4 antibody, in patients with advanced solid tumors: A phase I dose-escalation study
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DOI: 10.1158/1538-7445.am2024-ct097
Abstract: Background: IMM27M is a humanized Fc-engineered IgG1 CTLA-4 monoclonal antibody with enhanced ADCC. In pre-clinical models, IMM27M could enhance immune responses and promote Treg depletion. The pre-clinical results showed IMM27M induced a significantly stronger anti-tumor… read more here.
Keywords: escalation study; solid tumors; dose escalation; phase dose ... See more keywords
Abstract CT167: Trial in progress: Phase 1 dose escalation study of T-1101, a first-in-class oral Hec1/Nek2 inhibitor, in patients with advanced refractory solid tumors
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DOI: 10.1158/1538-7445.am2024-ct167
Abstract: Background: T-1101, a novel small molecule, is the first-in-class oral agent that specifically disrupts the interaction between two commonly overexpressed, critical mitotic regulators, Hec1 and Nek2, within cancer cells. Such disruption leads to abnormal mitosis… read more here.
Keywords: cancer; escalation study; dose escalation; escalation ... See more keywords
Vitamin D replacement in children with acute wheeze: a dose-escalation study
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DOI: 10.1183/23120541.00609-2021
Abstract: Meta-analyses report protective effects of vitamin D supplementation against asthma exacerbations and acute respiratory infections in adults [1–3], but data relating to effects of vitamin D on risk of preschool wheeze and asthma attacks in… read more here.
Keywords: supplementation; dose escalation; escalation study; wheeze ... See more keywords
Phase 1 single-center, dose escalation study of D2C7-IT administered intratumorally via convection-enhanced delivery for adult patients with recurrent malignant glioma.
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DOI: 10.1200/jco.2017.35.15_suppl.e13532
Abstract: e13532Background: D2C7 immunotoxin (D2C7-IT) is a dual-specific recombinant immunotoxin consisting of EGFR-wt and EGFRvIII monoclonal antibodies with a genetically engineered Pseudomonas exotoxin, ... read more here.
Keywords: single center; d2c7; dose escalation; escalation study ... See more keywords
Preliminary safety and pharmacodynamic (PD) activity of XmAb20717, a PD-1 x CTLA-4 bispecific antibody, in a phase I dose escalation study of patients with selected advanced solid tumors.
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DOI: 10.1200/jco.2020.38.15_suppl.e15001
Abstract: e15001Background: Interim safety and PD data from an ongoing first-in-human, multi-center, open-label dose escalation study of XmAb20717 (XmAb20717-01; NCT03517488) are reported here. The primary o... read more here.
Keywords: xmab20717; safety; escalation study; dose escalation ... See more keywords
A phase I/II dose-escalation study of fractionated and multiple dose 225Ac-J591 for progressive metastatic castration-resistant prostate cancer (mCRPC).
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DOI: 10.1200/jco.2021.39.6_suppl.tps188
Abstract: TPS188Background: Prostate-specific membrane antigen (PSMA)-based targeted radionuclide therapy (TRT) is a promising treatment. PSMA-targeting via large antibodies vs small molecules has different ... read more here.
Keywords: escalation study; prostate; study fractionated; dose escalation ... See more keywords
A Phase 1 Dose-Escalation Study of PF-06671008, a Bispecific T-Cell-Engaging Therapy Targeting P-Cadherin in Patients With Advanced Solid Tumors
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DOI: 10.3389/fimmu.2022.845417
Abstract: P-cadherin is a cell-cell adhesion molecule that is overexpressed in several solid tumors. PF-06671008 is a T-cell–redirecting bispecific antibody that engages both P-cadherin on tumors and CD3ϵ on T cells and induces antitumor activity in… read more here.
Keywords: cell; dose escalation; escalation study; phase dose ... See more keywords