A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids
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DOI: 10.1038/s41467-018-07898-0
Abstract: CD1 proteins are expressed on dendritic cells, where they display lipid antigens to T-cell receptors (TCRs). Here we describe T-cell autoreactivity towards ubiquitous human membrane phospholipids presented by CD1b. These T-cells discriminate between two major… read more here.
Keywords: escape channel; cell receptor; membrane phospholipids; cell ... See more keywords