Cell-Penetrating Peptides Escape the Endosome by Inducing Vesicle Budding and Collapse.
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DOI: 10.1021/acschembio.0c00478
Abstract: Cell-penetrating peptides (CPPs) are capable of delivering membrane-impermeable cargoes (including small molecules, peptides, proteins, nucleic acids, and nanoparticles) into the cytosol of mammalian cells and have the potential to revolu-tionize biomedical research and drug discovery.… read more here.
Keywords: penetrating peptides; endosome inducing; budding collapse; escape endosome ... See more keywords
Bacterial Toxins Escape the Endosome by Inducing Vesicle Budding and Collapse.
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DOI: 10.1021/acschembio.1c00540
Abstract: Bacterial protein toxins autonomously enter the cytosol of the target cell where they modify the activities of host components to exert their toxic effects. Many of the toxins enter the host cell by endocytosis followed… read more here.
Keywords: endosome inducing; budding collapse; escape endosome; bacterial toxins ... See more keywords
Discovery of a Small Molecule Inhibitor of Human Adenovirus Capable of Preventing Escape from the Endosome
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DOI: 10.3390/ijms22041617
Abstract: Human adenoviruses (HAdVs) display a wide range of tissue tropism and can cause an array of symptoms from mild respiratory illnesses to disseminated and life-threatening infections in immunocompromised individuals. However, no antiviral drug has been… read more here.
Keywords: molecule inhibitor; discovery small; inhibitor; small molecule ... See more keywords