Luteolin escape mutants of dengue virus map to prM and NS2B and reveal viral plasticity during maturation
Sign Up to like & getrecommendations! Published in 2018 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2018.04.013
Abstract: ABSTRACT We previously showed that luteolin, a well‐known plant‐derived component found in the “heat clearing” class of Traditional Chinese Medicine (TCM) herbs, is an uncompetitive inhibitor (Ki 58.6&mgr;M) of the host proprotein convertase furin, an… read more here.
Keywords: escape mutants; luteolin; virus; ns2b i114m ... See more keywords
Severe acute respiratory syndrome coronavirus 2 escape mutants and protective immunity from natural infections or immunizations
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Microbiology and Infection"
DOI: 10.1016/j.cmi.2021.03.011
Abstract: Although coronaviruses have lower mutation rates than other respiratory RNA viruses, the scale of the pandemic has brought the importance of viral evolution for coronaviruses to centre stage. Three recently detected SARS-CoV-2 lineages (B.1.1.7, B.1.351,… read more here.
Keywords: respiratory syndrome; severe acute; coronavirus escape; syndrome coronavirus ... See more keywords
Pleiotropic effects of hemagglutinin amino acid substitutions of influenza A(H1N1)pdm09 virus escape mutants.
Sign Up to like & getrecommendations! Published in 2018 at "Virus research"
DOI: 10.1016/j.virusres.2018.05.002
Abstract: In the present study we assessed pleiotropic characteristics of the antibody-selected mutations. We investigated pH optimum of fusion, temperatures of HA heat inactivation, in vivo and in vitro replication kinetics, and connectivity with panel of… read more here.
Keywords: amino acid; pleiotropic effects; escape mutants; acid substitutions ... See more keywords
Mutations in the envelope protein associated with hepatitis B virus reactivation
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DOI: 10.1111/hepr.13619
Abstract: Hepatitis B virus reactivation (HBVr) following cancer chemotherapy or immunosuppressive therapies can occur via both virological and host factors. In the current issue of Hepatology Research, Tsuruya et al. from the TokaiUniversity School of Medicine… read more here.
Keywords: hepatitis; hbv; envelope protein; escape mutants ... See more keywords
Characterization of hepatitis B virus in Amerindian children and mothers from Amazonas State, Colombia
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DOI: 10.1371/journal.pone.0181643
Abstract: Background Hepatitis B Virus (HBV) infection is a worldwide public health problem. In the 1980’s a highly effective and safe vaccine against HBV was developed, although breakthrough infection still occasionally occurs because of the emergence… read more here.
Keywords: escape mutants; amazonas state; hepatitis virus; children mothers ... See more keywords
Hepatitis B Virus Reactivation upon Immunosuppression: Is There a Role for Hepatitis B Core-Related Antigen in Patients with Immune-Escape Mutants? A Case Report
Sign Up to like & getrecommendations! Published in 2021 at "Diagnostics"
DOI: 10.3390/diagnostics11122185
Abstract: The reactivation of hepatitis B virus (HBVr) in patients undergoing pharmacological immunosuppression is a potentially fatal clinical event that may occur in patients with overt or occult HBV infection. The risk of HBVr is mainly… read more here.
Keywords: escape mutants; antigen; reactivation; immune escape ... See more keywords
Characterization of SARS-CoV-2 Escape Mutants to a Pair of Neutralizing Antibodies Targeting the RBD and the NTD
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23158177
Abstract: Mutations in the spike protein of SARS-CoV-2 can lead to evasion from neutralizing antibodies and affect the efficacy of passive and active immunization strategies. Immunization of mice harboring an entire set of human immunoglobulin variable… read more here.
Keywords: escape mutants; ntd; rbd; cluster ... See more keywords
Patterns of hepatitis B virus S gene escape mutants and reverse transcriptase mutations among genotype D isolates in Jordan
Sign Up to like & getrecommendations! Published in 2019 at "PeerJ"
DOI: 10.7717/peerj.6583
Abstract: Background Hepatitis B virus (HBV) is an important infectious cause of morbidity and mortality in Jordan. HBV genotype D is the most prevalent in the country. Virus escape mutants in the HBV S region is… read more here.
Keywords: hbv; hepatitis virus; escape mutants; reverse transcriptase ... See more keywords