High frequency of CD8 escape mutations in elite controllers as new obstacle for HIV cure
Sign Up to like & getrecommendations! Published in 2022 at "Virulence"
DOI: 10.1080/21505594.2022.2129353
Abstract: ABSTRACT Accumulation of mutations in epitopes of cytolytic-T-lymphocytes immune response (CTL) in HIV-reservoir seems to be one of the reasons for shock-and-kill strategy failure. Ten non-controller patients on successful cART (TX) and seven elite controllers… read more here.
Keywords: elite controllers; hiv; escape mutations; hiv gag ... See more keywords
Role of CD8+ T Cells in the Selection of HIV-1 Immune Escape Mutations.
Sign Up to like & getrecommendations! Published in 2017 at "Viral immunology"
DOI: 10.1089/vim.2016.0095
Abstract: Human immunodeficiency virus type-1 (HIV-1) infection represents one of the biggest public health problems worldwide. The immune response, mainly the effector mechanisms mediated by CD8+ T cells, induces the selection of mutations that allows the… read more here.
Keywords: escape; cd8 cells; hiv; selection ... See more keywords
Molecular Modeling Predicts Novel Antibody Escape Mutations in the Respiratory Syncytial Virus Fusion Glycoprotein
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00353-22
Abstract: Respiratory syncytial virus (RSV) causes severe disease in young infants, particularly those with heart or lung diseases or born prematurely. Because no vaccine is currently available, monoclonal antibodies are used to prevent severe RSV disease… read more here.
Keywords: escape mutations; syncytial virus; disease; respiratory syncytial ... See more keywords
No Difference in the Prevalence of HIV-1 gag Cytotoxic T-Lymphocyte-Associated Escape Mutations in Viral Sequences from Early and Late Parts of the HIV-1 Subtype C Pandemic in Botswana
Sign Up to like & getrecommendations! Published in 2023 at "Vaccines"
DOI: 10.3390/vaccines11051000
Abstract: HIV is known to accumulate escape mutations in the gag gene in response to the immune response from cytotoxic T lymphocytes (CTLs). These mutations can occur within an individual as well as at a population… read more here.
Keywords: time; hiv; escape mutations; prevalence ... See more keywords
Hepatitis B virus subgenotype F3 reactivation with vaccine escape mutations: A case report and review of the literature
Sign Up to like & getrecommendations! Published in 2018 at "World Journal of Hepatology"
DOI: 10.4254/wjh.v10.i7.509
Abstract: Hepatitis B represents a global health threat because its chronic course and sequelae contribute to a high morbidity and mortality. Hepatitis B virus (HBV) infection can be controlled by vaccines, antiviral treatment, and by interrupting… read more here.
Keywords: vaccine escape; vaccine; hepatitis virus; escape mutations ... See more keywords