Flaviviridae viruses use a common molecular mechanism to escape nucleoside analogue inhibitors.
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DOI: 10.1016/j.bbrc.2017.03.068
Abstract: The RNA-dependent RNA polymerases of Flaviviridae viruses are crucial for replication. The Flaviviridae polymerase is organized into structural motifs (A-G), with motifs F, A, C and E containing interrogating, priming and catalytic substrate-interacting sites. Modified… read more here.
Keywords: flaviviridae viruses; analogue inhibitors; threonine; nucleoside analogue ... See more keywords