Effectiveness of Fosfomycin for the Treatment of Multidrug-Resistant Escherichia coli Bacteremic Urinary Tract Infections
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.37277
Abstract: This randomized clinical trial investigates noninferiority of fosfomycin vs ceftriaxone or meropenem in achieving clinical and microbiological cure among patients with urinary tract infections due to multidrug-resistant Escherichia coli. read more here.
Keywords: escherichia coli; urinary tract; resistant escherichia; tract infections ... See more keywords
Escherichia coli YegI is a novel Ser/Thr kinase lacking conserved motifs that localizes to the inner membrane
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13920
Abstract: In bacteria, signaling phosphorylation is thought to occur primarily on His and Asp residues. However, phosphoproteomic surveys in phylogenetically diverse bacteria over the past decade have identified numerous proteins that are phosphorylated on Ser and/or… read more here.
Keywords: escherichia coli; thr; thr kinase; novel ser ... See more keywords
The clinically relevant triple mutation in the mtND1 gene inactivates Escherichia coli complex I.
Sign Up to like & getrecommendations! Published in 2022 at "FEBS letters"
DOI: 10.1002/1873-3468.14325
Abstract: NADH:ubiquinone oxidoreductase (respiratory complex I) plays a major role in cellular energy metabolism. Complex I deficiencies are the most common cause of mitochondrial dysfunction. Patients suffering from a variety of neurodegenerative diseases carry numerous mutations… read more here.
Keywords: relevant triple; escherichia coli; triple mutation; mtnd1 ... See more keywords
Production of Rainbow Colorants by Metabolically Engineered Escherichia coli
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DOI: 10.1002/advs.202100743
Abstract: Abstract There has been much interest in producing natural colorants to replace synthetic colorants of health concerns. Escherichia coli has been employed to produce natural colorants including carotenoids, indigo, anthocyanins, and violacein. However, production of… read more here.
Keywords: engineering; production; rainbow colorants; production rainbow ... See more keywords
Mechanistic study of the antibacterial potential of the prenylated flavonoid auriculasin against Escherichia coli
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DOI: 10.1002/ardp.202200360
Abstract: Bacterial resistance is spreading in an alarming manner, outpacing the rate of development of new antibacterial agents and surging the need for effective alternatives. Prenylated flavonoids are a promising class of natural antibiotics with reported… read more here.
Keywords: gyr; escherichia coli; prenylated flavonoids; mechanistic study ... See more keywords
Biosynthesis of bioactive tamarixetin in recombinant Escherichia coli
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1958
Abstract: Tamarixetin, a monomethylated derivative of quercetin, has been reported to possess many important biological activities. In the present study, a whole cell biotransformation system was used for regiospecific methylation of quercetin to produce 4′‐O‐methylated quercetin… read more here.
Keywords: escherichia coli; methylated quercetin; tamarixetin; quercetin ... See more keywords
Overexpression of the key genes in the biosynthetic pathways of lipid A and peptidoglycan in Escherichia coli
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DOI: 10.1002/bab.2364
Abstract: Gram‐negative bacterium Escherichia coli has a tripartite cell envelope with a cytoplasmic membrane, a peptidoglycan layer, and an asymmetric outer membrane containing lipopolysaccharide in its outer leaflet. The biogenesis of peptidoglycan and lipopolysaccharide shares the… read more here.
Keywords: cell; key genes; escherichia coli; overexpression ... See more keywords
Metabolic engineering of Escherichia coli to efficiently produce monophosphoryl lipid A.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2443
Abstract: Monophosphoryl lipid A, mainly isolated from Salmonella minnesota R595, has been used as adjuvant in several vaccines. In this study, an Escherichia coli strain that can efficiently produce the monophosphoryl lipid A has been constructed.… read more here.
Keywords: escherichia coli; monophosphoryl lipid; efficiently produce; mw012 pwepl ... See more keywords
Optimization of glycerol consumption in wild‐type Escherichia coli using central carbon modeling as an alternative approach
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DOI: 10.1002/bbb.2205
Abstract: The development of a culture medium is an essential step in any bioprocess involving microorganisms for the bioconversion of by‐products to valuable chemicals, making industries like the biofuel industry more competitive. Optimization of the bioconversion… read more here.
Keywords: glycerol consumption; escherichia coli; medium; glycerol ... See more keywords
Adaptive Evolution in Producing Microtiter Cultivations Generates Genetically Stable Escherichia coli Production Hosts for Continuous Bioprocessing
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DOI: 10.1002/biot.202000376
Abstract: The production of recombinant proteins usually reduces cell fitness and the growth rate of producing cells. The growth disadvantage favors faster‐growing non‐producer mutants. Therefore, continuous bioprocessing is hardly feasible in Escherichia coli due to the… read more here.
Keywords: continuous bioprocessing; production; escherichia coli; long term ... See more keywords
Simultaneous production of 2′‐fucosyllactose and difucosyllactose by engineered Escherichia coli with high secretion efficiency
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Journal"
DOI: 10.1002/biot.202100629
Abstract: Difucosyllactose (Di‐FL) has strong antimicrobial activity against various pathogens, including group B Streptococcus, identified as the leading cause of neonatal sepsis. In this study, we sought to develop Escherichia coli as a microbial cell factory… read more here.
Keywords: fucosyllactose difucosyllactose; difucosyllactose engineered; escherichia coli; simultaneous production ... See more keywords