Screening of Interactions with the ESCRT Machinery by a Gaussia princeps Split Luciferase-Based Complementation Assay.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9492-2_21
Abstract: The endosomal sorting complex required for transport (ESCRT) machinery comprises five complexes that act sequentially to recruit and cluster transmembrane cargo proteins (ESCRT-0), drive membrane curving (ESCRT-I and II), catalyze fission of cargo-containing vesicles (ESCRT-III… read more here.
Keywords: complementation; interactions escrt; escrt machinery; split luciferase ... See more keywords
The Dynamics of TGF-β Signaling Are Dictated by Receptor Trafficking via the ESCRT Machinery.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.10.056
Abstract: Signal transduction pathways stimulated by secreted growth factors are tightly regulated at multiple levels between the cell surface and the nucleus. The trafficking of cell surface receptors is emerging as a key step for regulating… read more here.
Keywords: dictated receptor; tgf signaling; machinery; signaling dictated ... See more keywords
Triggered recruitment of ESCRT machinery promotes endolysosomal repair
Sign Up to like & getrecommendations! Published in 2018 at "Science"
DOI: 10.1126/science.aar5078
Abstract: A quick fix for leaky endosomes Cells internalize diverse material through various forms of endocytosis into an extensive endolysosomal network. Protecting the integrity of endolysosomal membranes in both physiological and pathophysiological contexts is critical to… read more here.
Keywords: machinery; escrt machinery; damage; membrane ... See more keywords
Lethal (2) giant discs (Lgd)/CC2D1 is required for the full activity of the ESCRT machinery
Sign Up to like & getrecommendations! Published in 2020 at "BMC Biology"
DOI: 10.1186/s12915-020-00933-x
Abstract: Background A major task of the endosomal sorting complex required for transport (ESCRT) machinery is the pinching off of cargo-loaded intraluminal vesicles (ILVs) into the lumen of maturing endosomes (MEs), which is essential for the… read more here.
Keywords: escrt iii; lgd; shrub; escrt machinery ... See more keywords
Unexpected organellar locations of ESCRT machinery in Giardia intestinalis and complex evolutionary dynamics spanning the transition to parasitism in the lineage Fornicata
Sign Up to like & getrecommendations! Published in 2021 at "BMC Biology"
DOI: 10.1186/s12915-021-01077-2
Abstract: Background Comparing a parasitic lineage to its free-living relatives is a powerful way to understand how that evolutionary transition to parasitism occurred. Giardia intestinalis (Fornicata) is a leading cause of gastrointestinal disease world-wide and is… read more here.
Keywords: giardia intestinalis; transition parasitism; giardia; escrt machinery ... See more keywords
Toxoplasma gondii exploits the host ESCRT machinery for parasite uptake of host cytosolic proteins
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010138
Abstract: Toxoplasma gondii is a master manipulator capable of effectively siphoning the resources from the host cell for its intracellular subsistence. However, the molecular underpinnings of how the parasite gains resources from its host remain largely… read more here.
Keywords: host cytosolic; escrt machinery; gondii; host ... See more keywords
The multifaceted interactions between pathogens and host ESCRT machinery
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1011344
Abstract: The Endosomal Sorting Complex Required for Transport (ESCRT) machinery consists of multiple protein complexes that coordinate vesicle budding away from the host cytosol. ESCRTs function in many fundamental cellular processes including the biogenesis of multivesicular… read more here.
Keywords: multifaceted interactions; interactions pathogens; host escrt; machinery ... See more keywords
The ESCRT Machinery: Remodeling, Repairing, and Sealing Membranes
Sign Up to like & getrecommendations! Published in 2022 at "Membranes"
DOI: 10.3390/membranes12060633
Abstract: The ESCRT machinery is an evolutionarily conserved membrane remodeling complex that is used by the cell to perform reverse membrane scission in essential processes like protein degradation, cell division, and release of enveloped retroviruses. ESCRT-III,… read more here.
Keywords: escrt machinery; remodeling repairing; machinery remodeling; escrt iii ... See more keywords