Esculetin alleviates murine lupus nephritis by inhibiting complement activation and enhancing Nrf2 signaling pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2022.115004
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Esculetin is a bioactive compound of medicinal herb Hydrangea paniculata, and has showed anti-oxidation and anti-inflammation bioactivities. Renal local oxidative stress and inflammation are import contributors for progression of lupus nephritis (LN). AIM… read more here.
Keywords: esculetin could; lupus nephritis; pathway; complement activation ... See more keywords
Oral bioavailability and pharmacokinetics of esculetin following intravenous and oral administration in rats
Sign Up to like & getrecommendations! Published in 2021 at "Xenobiotica"
DOI: 10.1080/00498254.2021.1925774
Abstract: Abstract Esculetin is the main active ingredient isolated from Artemisia montana (Nakai) Pamp. and Euphorbia lathyris L. The present study investigated the oral bioavailability and pharmacokinetics of esculetin in rats, following intravenous and oral administration.… read more here.
Keywords: oral bioavailability; bioavailability pharmacokinetics; intravenous oral; esculetin ... See more keywords
Activation of Nrf2 by Esculetin Mitigates Inflammatory Responses through Suppression of NF-κB Signaling Cascade in RAW 264.7 Cells
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DOI: 10.3390/molecules27165143
Abstract: Inflammation is a major root of several diseases such as allergy, cancer, Alzheimer’s, and several others, and the present state of existing drugs provoked researchers to search for new treatment strategies. Plants are regarded to… read more here.
Keywords: esculetin; 264 cells; expression; lta induced ... See more keywords