Evaluation of Ethnicity Effect on Intranasal Esketamine Pharmacokinetics by Population Pharmacokinetic Modeling Using Data From a Japanese Phase 2b Study
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DOI: 10.1002/cpdd.1214
Abstract: Esketamine is used for the treatment of treatment‐resistant depression in many countries. A population pharmacokinetic (popPK) model of esketamine and its metabolite (noresketamine) has been previously developed, which included Asian race and Japanese ethnicity as… read more here.
Keywords: ethnicity; population pharmacokinetic; esketamine; model ... See more keywords
Esketamine nasal spray for treatment‐resistant depression
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DOI: 10.1002/psb.1845
Abstract: A nasal spray formulation of esketamine (Spravato) was licensed as adjunctive therapy for the management of adults with treatment‐resistant major depression in December. This article discusses the properties, clinical trial efficacy and adverse effects of… read more here.
Keywords: treatment; treatment resistant; esketamine; nasal spray ... See more keywords
Appraising esketamine nasal spray for the management of treatment-resistant depression in adults: Number needed to treat, number needed to harm, and likelihood to be helped or harmed.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2020.03.106
Abstract: INTRODUCTION This post hoc study assessed the evidence-base for esketamine nasal spray for management of treatment-resistant depression (TRD) using number needed to treat (NNT), number needed to harm (NNH), and likelihood to be helped or… read more here.
Keywords: nasal spray; esketamine nasal; esketamine; number needed ... See more keywords
The efficacy and safety of adjunctive intranasal esketamine treatment in major depressive disorder: a systematic review and meta-analysis
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DOI: 10.1080/14740338.2022.2058488
Abstract: ABSTRACT Introduction Intranasal (IN) esketamine represents an innovative treatment for individuals with treatment resistant depression and depression with suicidal ideation and behavior. Herein, we synthesize extant long-term studies (≥ 4 weeks) regarding this treatment. Research… read more here.
Keywords: treatment; intranasal esketamine; esketamine; meta analysis ... See more keywords
Craving and addictive potential of esketamine as side effects?
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DOI: 10.1080/14740338.2022.2071422
Abstract: ABSTRACT Introduction Esketamine was approved for adults with treatment-resistant depression (TRD) in conjunction with an oral antidepressant, and for treating depressive symptoms in adults with major depressive disorder with acute suicidal ideation or behavior. However,… read more here.
Keywords: esketamine side; potential esketamine; symptomatology; craving addictive ... See more keywords
Pharmacokinetics and Bioavailability of Inhaled Esketamine in Healthy Volunteers
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DOI: 10.1097/aln.0000000000001798
Abstract: Background: Esketamine is traditionally administered via intravenous or intramuscular routes. In this study we developed a pharmacokinetic model of inhalation of nebulized esketamine with special emphasis on pulmonary absorption and bioavailability. Methods: Three increasing doses… read more here.
Keywords: esketamine; bioavailability; healthy volunteers; esketamine healthy ... See more keywords
Esketamine for Unipolar Major Depression With Psychotic Features
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DOI: 10.1097/jcp.0000000000001571
Abstract: Abstract Purposes/Background The aims of the study were to assess subanesthetic esketamine as an antidepressant for major depressive disorder with psychotic features (PMDD) and to compare posttreatment symptoms among those with PMDD to a sample… read more here.
Keywords: psychotic features; depression; psychotic symptoms; major depression ... See more keywords
Effect of esketamine on opioid consumption and postoperative pain in thyroidectomy: a randomized controlled trial.
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DOI: 10.1111/bcp.15726
Abstract: AIM Thyroidectomy is frequently associated with substantial postoperative pain. Esketamine, an N-methyl-D-aspartate receptor antagonist, has been demonstrated to be effective in multiple analgesia scenarios. We hypothesized that intraoperative administration of esketamine may reduce perioperative opioid… read more here.
Keywords: postoperative pain; group; esketamine; consumption postoperative ... See more keywords
Clinical effects of low‐dose esketamine for anaesthesia induction in the elderly: A randomized controlled trial
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DOI: 10.1111/jcpt.13604
Abstract: Esketamine is an N‐methyl‐D‐aspartic acid (NMDA) receptor antagonist, which has stronger sedative and analgesic effects and fewer adverse events than ketamine. The effects of low‐dose esketamine on haemodynamics and postoperative quality of recovery in elderly… read more here.
Keywords: induction elderly; effects low; anaesthesia induction; dose esketamine ... See more keywords
Esketamine Increases Neurotransmitter Releases but Simplifies Neurotransmitter Networks in Mouse Prefrontal Cortex.
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DOI: 10.1152/jn.00462.2021
Abstract: General anesthesia induces a profound but reversible unconscious state, which is accompanied by changes in various neurotransmitters in the cortex. Unlike the "brain silencing" effect of γ-aminobutyric acid (GABA) receptor potentiator anesthesia, ketamine anesthesia leads… read more here.
Keywords: increases neurotransmitter; esketamine increases; esketamine; neurotransmitter releases ... See more keywords
Efficacy of Analgesic Propofol/Esketamine and Propofol/Fentanyl for Painless Induced Abortion: A Randomized Clinical Trial
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DOI: 10.1155/2022/5095282
Abstract: Background Patients have widely accepted abortion as a remedy for contraceptive failure all over the world. Esketamine is a new anesthetic, sedative, and analgesic drug. Fentanyl is an opioid receptor agonist and a commonly used… read more here.
Keywords: abortion; painless induced; propofol; group ... See more keywords