Phase 1 and preclinical profiling of ESM‐HDAC391, a myeloid‐targeted histone deacetylase inhibitor, shows enhanced pharmacology and monocytopaenia
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.15428
Abstract: To improve the tolerability and therapeutic application of histone deacetylase inhibitors (HDACi), by application of an esterase‐sensitive motif (ESM), to target pharmacological activity directly to mononuclear myeloid cells expressing the processing enzyme carboxylesterase‐1 (CES1). read more here.
Keywords: pharmacology; phase preclinical; myeloid; esm ... See more keywords
Shape-preserving elastic solid models of macromolecules
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1007855
Abstract: Mass-spring models have been a standard approach in molecular modeling for the last few decades, such as elastic network models (ENMs) that are widely used for normal mode analysis. In this work, we present a… read more here.
Keywords: preserving elastic; models macromolecules; solid models; shape preserving ... See more keywords
The extracellular matrix of eggshell displays anti-inflammatory activities through NF-κB in LPS-triggered human immune cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s130974
Abstract: Avian eggshell membrane (ESM) is a natural biomaterial that has been used as an alternative natural bandage on burned and cut skin injuries for >400 years in Asian countries, and is available in large quantities… read more here.
Keywords: anti inflammatory; carbohydrate fraction; processed esm; esm powder ... See more keywords
Dietary Eggshell Membrane Powder Improves Survival Rate and Ameliorates Gut Dysbiosis in Interleukin-10 Knockout Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2022.895665
Abstract: Inflammatory bowel disease (IBD) is known to be associated with compositional and metabolic changes in the gut microbiota. The aim of this study was to investigate whether dietary eggshell membrane (ESM) improves survival rate or… read more here.
Keywords: dietary eggshell; eggshell membrane; mice; survival rate ... See more keywords
A Moderated Mediation Model Linking Excessive Enterprise Social Media Usage With Job Performance
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Psychology"
DOI: 10.3389/fpsyg.2022.884946
Abstract: Despite the larger interest of information systems scholars in excessive ESM usage, little is known about how excessive ESM usage is related to employee performance. This study focused on excessive ESM usage and investigated its… read more here.
Keywords: esm usage; esm; employee performance; excessive esm ... See more keywords
Therapeutic Application of an Ag-Nanoparticle-PNIPAAm-Modified Eggshell Membrane Construct for Dermal Regeneration and Reconstruction
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14102162
Abstract: Current therapeutic treatments for the repair and/or replacement of damaged skin following disease or traumatic injury is severely limited. The chicken eggshell membrane (ESM) is a unique material: its innate physical and mechanical characteristics offer… read more here.
Keywords: eggshell membrane; pnipaam; release; viability ... See more keywords