Hormonal Modulation of ESR1 Mutant Metastasis
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DOI: 10.1038/s41388-020-01563-x
Abstract: Estrogen receptor alpha gene (ESR1) mutations occur frequently in ER-positive metastatic breast cancer, and confer clinical resistance to aromatase inhibitors. Expression of the ESR1 Y537S mutation induced an epithelial–mesenchymal transition (EMT) with cells exhibiting enhanced… read more here.
Keywords: modulation esr1; breast cancer; metastasis; esr1 mutant ... See more keywords
Abstract 3889: The role of CXCL1 in crosstalk between breast cancer cells with ESR1 mutations and lymphatic endothelial cells
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DOI: 10.1158/1538-7445.am2023-3889
Abstract: Various endocrine therapies have been developed such as selective estrogen receptor modulation (SERM), selective estrogen receptor downregulator (SERD) and ligand deprivation using aromatase inhibitors (AI). Tamoxifen, fulvestrant, and AIs are the most used adjuvant treatment… read more here.
Keywords: crosstalk; breast cancer; cancer; esr1 mutant ... See more keywords
Abstract P6-03-06:ESR1mutant alleles induce differential sensitivity to combination endocrine and targeted therapies
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DOI: 10.1158/1538-7445.sabcs19-p6-03-06
Abstract: Background: Estrogen receptor alpha (ESR1) mutations in estrogen receptor positive (ER+) metastatic breast cancer drive the development of acquired resistance to endocrine therapy. However, ESR1 mutation status does not currently guide treatment decisions due to… read more here.
Keywords: combination; treatment; esr1 mutant; sensitivity ... See more keywords