Highly sensitive detection of ESR1 mutations in cell-free DNA from patients with metastatic breast cancer using molecular barcode sequencing
Sign Up to like & getrecommendations! Published in 2017 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-017-4487-y
Abstract: PurposeWe aimed to develop a highly sensitive method to detect ESR1 mutations in cell-free DNA (cfDNA) using next-generation sequencing with molecular barcode (MB–NGS) targeting the hotspot segment (c.1600–1713).MethodsThe sensitivity of MB–NGS was tested using serially… read more here.
Keywords: breast; barcode; patients metastatic; breast cancer ... See more keywords
Immunohistochemical analysis of estrogen receptor in breast cancer with ESR1 mutations detected by hybrid capture-based next-generation sequencing
Sign Up to like & getrecommendations! Published in 2018 at "Modern Pathology"
DOI: 10.1038/s41379-018-0116-5
Abstract: Estrogen receptor-α (ER-α), encoded by ESR1, is detected by immunohistochemistry in approximately 70% of invasive breast cancers and serves as a strong predictive biomarker. ESR1-activating mutations in the ligand-binding domain have been reported in up… read more here.
Keywords: immunohistochemistry; breast; breast cancer; cancer ... See more keywords
Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance
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DOI: 10.1038/s41467-017-01864-y
Abstract: Resistance to endocrine therapy remains a major clinical problem in breast cancer. Genetic studies highlight the potential role of estrogen receptor-α (ESR1) mutations, which show increased prevalence in the metastatic, endocrine-resistant setting. No naturally occurring… read more here.
Keywords: breast cancer; resistance; naturally occurring; endocrine resistance ... See more keywords
Abstract 2220: Dynamic development of ESR1 mutations in circulating tumor DNA (ctDNA) is associated with prognosis of patients with metastatic breast cancer (MBC)
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DOI: 10.1158/1538-7445.am2023-2220
Abstract: Background: Relapse and endocrine resistance are major clinical challenges in the management of patients with MBC because it is a dynamic phenomenon including development of ESR1 mutations. The monitoring of ctDNA and circulating tumor cells… read more here.
Keywords: time; patients esr1; prognosis; time point ... See more keywords
Abstract 6701: 6-color Crystal Digital PCR for the high-plex detection of 10 ESR1 mutations in breast cancer
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DOI: 10.1158/1538-7445.am2023-6701
Abstract: Introduction. ESR1 mutations have emerged as a key mechanism of resistance to endocrine therapy in estrogen-receptor-positive (ER+) breast cancer, thus detection of ESR1 mutations is crucial to monitor during patient treatment. We evaluated a novel… read more here.
Keywords: color; esr1 mutations; breast cancer; crystal digital ... See more keywords
Abstract P4-04-09: New oral SERD elacestrant (RAD1901) shows efficacy in breast cancer models harbouring ESR1 mutations and enhances the antiproliferative activity of mTORC1 and CDK4/6 inhibitors
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs17-p4-04-09
Abstract: Background: Targeting estrogen receptor (ER) signalling is the main therapeutic option for ER+ breast cancer (BC). However, over 30% of patients relapse with endocrine resistance emphasising the need for improved therapeutic strategies. The prevalence of… read more here.
Keywords: elacestrant; cdk4; breast cancer; cancer ... See more keywords
Abstract PD8-08: ESR1 mutations confer novel metastatic functions in genome-edited breast cancer cell models
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DOI: 10.1158/1538-7445.sabcs17-pd8-08
Abstract: Background: Estrogen receptor alpha (ERα), encoded by the ESR1 gene, is expressed in approximately 70% of breast cancers. Recent studies conducted by us and others have shown that somatic mutations in ESR1 gene play a… read more here.
Keywords: cell models; breast cancer; cancer; cell ... See more keywords
ESR1 mutations associated with EIS change conformation of ligand receptor complex and alter transcriptome profile.
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DOI: 10.1210/endocr/bqaa050
Abstract: Estrogen insensitivity syndrome (EIS) arises from rare mutations in estrogen receptor α (ERα, encoded by ESR1 gene) resulting in the inability of estrogen to exert its biological effects. Due to the rarity, mutations in ESR1… read more here.
Keywords: change conformation; receptor; conformation ligand; esr1 ... See more keywords
The predictive ability of plasma ESR1 mutations for the efficacy of endocrine therapy in hormone-receptor-positive advanced breast cancer
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DOI: 10.2147/ott.s171465
Abstract: Purpose The predictive ability of plasma ESR1 mutations for outcomes among patients with advanced breast cancer undergoing endocrine therapy (ET) remains disputable. We performed a comprehensive meta-analysis of published studies to clarify the impact of… read more here.
Keywords: plasma esr1; breast cancer; esr1 mutations; advanced breast ... See more keywords
The Emerging Role of ESR1 Mutations in Luminal Breast Cancer as a Prognostic and Predictive Biomarker of Response to Endocrine Therapy
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DOI: 10.3390/cancers11121894
Abstract: Mutations in the hotspot ligand-binding domain of the estrogen receptor (ER) gene ESR1 have recently been recognized as mechanisms of endocrine resistance in endocrine receptor-positive metastatic breast cancer (MBC). Accumulating data suggest these mutations develop… read more here.
Keywords: breast; luminal breast; breast cancer; endocrine ... See more keywords
Detection of ESR1 Mutations in Primary Tumors and Plasma Cell-Free DNA in High-Grade Serous Ovarian Carcinoma Patients
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DOI: 10.3390/cancers14153790
Abstract: Simple Summary In the present study we evaluated the frequency and the clinical relevance of ESR1 mutations in high-grade serous ovarian cancer (HGSOC). Drop-off droplet digital PCR (ddPCR) was first used to screen for ESR1… read more here.
Keywords: high grade; grade serous; ovarian cancer; esr1 mutations ... See more keywords