p38γ is essential for cell cycle progression and liver tumorigenesis
Sign Up to like & getrecommendations! Published in 2019 at "Nature"
DOI: 10.1038/s41586-019-1112-8
Abstract: The cell cycle is a tightly regulated process that is controlled by the conserved cyclin-dependent kinase (CDK)–cyclin protein complex1. However, control of the G0-to-G1 transition is not completely understood. Here we demonstrate that p38 MAPK… read more here.
Keywords: p38; p38 essential; essential cell; cell cycle ... See more keywords
Metabolic function of autophagy is essential for cell survival.
Sign Up to like & getrecommendations! Published in 2023 at "Autophagy"
DOI: 10.1080/15548627.2023.2165753
Abstract: Age-related human pathologies present with a multitude of molecular and metabolic phenotypes, which individually or synergistically contribute to tissue degeneration. However, current lack of understanding of the interdependence of these molecular pathologies limits the potential… read more here.
Keywords: metabolic function; essential cell; age related; autophagy essential ... See more keywords
Repression of essential cell cycle genes increases cellular fitness
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1010349
Abstract: A network of transcription factors (TFs) coordinates transcription with cell cycle events in eukaryotes. Most TFs in the network are phosphorylated by cyclin-dependent kinase (CDK), which limits their activities during the cell cycle. Here, we… read more here.
Keywords: cycle; essential cell; yhp1 yox1; cell cycle ... See more keywords
Polypyrimidine tract-binding proteins are essential for B cell development
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.53557
Abstract: Polypyrimidine tract-binding protein 1 (PTBP1) is a RNA-binding protein (RBP) expressed throughout B cell development. Deletion of Ptbp1 in mouse pro-B cells results in upregulation of PTBP2 and normal B cell development. We show that… read more here.
Keywords: polypyrimidine tract; cell; essential cell; cell development ... See more keywords