Defining essential charged residues in fibril formation of a lysosomal derived N-terminal α-synuclein truncation
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DOI: 10.1038/s41467-025-58899-9
Abstract: N- and C-terminal α-synuclein (α-syn) truncations are prevalent in Parkinson’s disease. Effects of the N- and C-terminal residues on α-syn aggregation and fibril propagation are distinct, where the N-terminus dictates fibril structure. Here, the majority… read more here.
Keywords: truncation; essential charged; terminal synuclein; residues fibril ... See more keywords