Delineation of functionally essential protein regions for 242 neurodevelopmental genes
Sign Up to like & getrecommendations! Published in 2022 at "Brain"
DOI: 10.1093/brain/awac381
Abstract: Abstract Neurodevelopmental disorders (NDDs), including severe paediatric epilepsy, autism and intellectual disabilities are heterogeneous conditions in which clinical genetic testing can often identify a pathogenic variant. For many of them, genetic therapies will be tested… read more here.
Keywords: essential protein; essential3d sites; delineation functionally; functionally essential ... See more keywords
A New Scheme for Essential Protein Identification Based on Uncertain Networks
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DOI: 10.1109/access.2020.2974897
Abstract: Identifying essential proteins is important for not only understanding cellular activity but also detecting human disease genes. A series of centrality measures have been proposed to identify essential proteins based on the protein-protein interaction (PPI)… read more here.
Keywords: ppi network; new scheme; essential protein; essential proteins ... See more keywords
Identification of Essential Protein Using Chemical Reaction Optimization and Machine Learning Technique.
Sign Up to like & getrecommendations! Published in 2023 at "IEEE/ACM transactions on computational biology and bioinformatics"
DOI: 10.1109/tcbb.2022.3233473
Abstract: For the survival, development, and reproduction of the organism, understanding the working process of the cell, disease study, design drugs, etc. essential protein plays a crucial role. Due to a large number of biological information,… read more here.
Keywords: chemical reaction; essential protein; machine learning; technique ... See more keywords