Prediction of protein essentiality by the improved particle swarm optimization
Sign Up to like & getrecommendations! Published in 2018 at "Soft Computing"
DOI: 10.1007/s00500-017-2964-1
Abstract: The essential protein is very important for understanding cellular critical activities and development. With the development of high throughput technology, how to identify the essential proteins from the protein interaction network has become a hot… read more here.
Keywords: protein; improved particle; network; topology ... See more keywords
A novel extended pareto optimality consensus model for predicting essential proteins.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2019.08.005
Abstract: Essential proteins have vital functions, when they are destroyed in cells, the cells will die or stop reproducing. Therefore, it is very important to identify essential proteins from a large number of other proteins. Due… read more here.
Keywords: information; importance; reliability ppis; model ... See more keywords
Essential proteins identification method based on four-order distances and subcellular localization information
Sign Up to like & getrecommendations! Published in 2023 at "Chinese Physics B"
DOI: 10.1088/1674-1056/acd7ca
Abstract: Essential proteins are inseparable in cell growth and survival. The study of essential proteins is important for understanding cellular functions and biological mechanisms, therefore there are various computable methods proposed to identify essential proteins. Unfortunately,… read more here.
Keywords: topology; localization information; subcellular localization; based four ... See more keywords
Accurate prediction of essential proteins using ensemble machine learning
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DOI: 10.1088/1674-1056/ad8db2
Abstract: Essential proteins are crucial for biological processes and can be identified through both experimental and computational methods. While experimental approaches are highly accurate, they often demand extensive time and resources. To address these challenges, we… read more here.
Keywords: accurate prediction; machine learning; proteins using; essential proteins ... See more keywords
A New Scheme for Essential Protein Identification Based on Uncertain Networks
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DOI: 10.1109/access.2020.2974897
Abstract: Identifying essential proteins is important for not only understanding cellular activity but also detecting human disease genes. A series of centrality measures have been proposed to identify essential proteins based on the protein-protein interaction (PPI)… read more here.
Keywords: ppi network; new scheme; essential protein; essential proteins ... See more keywords
An Iteration Method for Identifying Yeast Essential Proteins From Weighted PPI Network Based on Topological and Functional Features of Proteins
Sign Up to like & getrecommendations! Published in 2020 at "IEEE Access"
DOI: 10.1109/access.2020.2993860
Abstract: Accumulating studies have indicated that essential proteins play critical roles in numerous biological processes. With the rapid development of high-throughput technologies, a large number of Protein-Protein Interaction (PPI) data have been found in Saccharomyces cerevisiae,… read more here.
Keywords: essential proteins; prediction; ppi networks; ppi ... See more keywords
A Deep Learning Framework for Identifying Essential Proteins by Integrating Multiple Types of Biological Information
Sign Up to like & getrecommendations! Published in 2021 at "IEEE/ACM Transactions on Computational Biology and Bioinformatics"
DOI: 10.1109/tcbb.2019.2897679
Abstract: Computational methods including centrality and machine learning-based methods have been proposed to identify essential proteins for understanding the minimum requirements of the survival and evolution of a cell. In centrality methods, researchers are required to… read more here.
Keywords: learning framework; essential proteins; biological information; deep learning ... See more keywords
Predicting Essential Proteins by Integrating Network Topology, Subcellular Localization Information, Gene Expression Profile and GO Annotation Data
Sign Up to like & getrecommendations! Published in 2020 at "IEEE/ACM Transactions on Computational Biology and Bioinformatics"
DOI: 10.1109/tcbb.2019.2916038
Abstract: Essential proteins are indispensable for maintaining normal cellular functions. Identification of essential proteins from Protein-protein interaction (PPI) networks has become a hot topic in recent years. Traditionally biological experimental based approaches are time-consuming and expensive,… read more here.
Keywords: mml; essential proteins; topology; mml mml ... See more keywords
Constructing multilayer PPI networks based on homologous proteins and integrating multiple PageRank to identify essential proteins
Sign Up to like & getrecommendations! Published in 2025 at "BMC Bioinformatics"
DOI: 10.1186/s12859-025-06093-5
Abstract: Predicting and studying essential proteins not only helps to understand the fundamental requirements for cell survival and growth regulation mechanisms but also deepens our understanding of disease mechanisms and drives drug development. Existing methods for… read more here.
Keywords: ppi networks; homologous relationships; multiple pagerank; multilayer ppi ... See more keywords
A new computational strategy for identifying essential proteins based on network topological properties and biological information
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DOI: 10.1371/journal.pone.0182031
Abstract: Essential proteins are the proteins that are indispensable to the survival and development of an organism. Deleting a single essential protein will cause lethality or infertility. Identifying and analysing essential proteins are key to understanding… read more here.
Keywords: identifying essential; information; new computational; computational strategy ... See more keywords
An Automated Model for Target Protein Prediction in PPI
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DOI: 10.2174/1574893615999200831142241
Abstract: Essential proteins play a crucial role in most of the living organisms. The computer-based task of predicting essential proteins is important for target protein identification, disease treatment and suitable drug development. Traditionally many experimental and… read more here.
Keywords: essential proteins; target protein; automated model; model ... See more keywords